GSK046 (GSK-046, IBET-BD2)
GSK046 (iBET-BD2, GSK 046, GSK-046) (CAS No.: 2474876-09-8), a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4...
BI-3406
BI-3406 (CAS No.: 2230836-55-0), a highly potent, selective, and orally bioavailable inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. Synonyms: KRAS and Son of Sevenless 1...
Giredestrant (GDC-9545)
Giredestrant (GDC-9545, CAS No.: 1953133-47-5), an orally active and selective estrogen receptor antagonist, potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Synonyms: selective estrogen receptor degrader...
Volociximab Biosimilar, Anti-human Integrin α5β1 Antibody | C065P
The cheapest research grade volociximab biosimilar (anti-human integrin α5β1 monoclonal antibody, mAb) for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for...
TAK-931 (SIMUROSERTIB)
TAK-931 (CAS No.: 1330782-76-7), A Selective and ATP-Competitive Cell Division Cycle 7 (CDC7) Kinase Inhibitor. Synonyms: cell division cycle 7 inhibitor TAK-931, Simurosertib, TAK931, CDC7 kinase inhibitor
LYC-55716 (CINTIRORGON)
Cintirorgon (CAS No.: 2055536-64-4), is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression,...
Darovasertib (LXS-196, NVP-LXS196, IDE196)
Darovasertib (CAS No.: 1874276-76-2), is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has...
M-3258 (M3258, M 3258)
M-3258 (CAS No.: 2285330-15-4), orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. Synonyms: M3258, M 3258, M-3258,...
M-2698 (MSC2363318A)
M-2698 (CAS No.: 1379545-95-5), is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. >98% Purity. Synonyms: MSC2363318A, M2698, p70S6 inhibitor, Akt inhibitor For Research Use...