Giredestrant (GDC-9545)

Giredestrant (GDC-9545, CAS No.: 1953133-47-5), an orally active and selective estrogen receptor antagonist, potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain.

Synonyms: selective estrogen receptor degrader GDC-9545, selective estrogen receptor downregulator GDC-9545, SERD GDC-9545