Enzyme inhibitors and activators; receptor antagonists and agonists.
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Chemicals, Inhibitors, Activators, Antagonists, and AgonistsVactosertib (EW-7197, TEW-7197)
$70.00 – $450.00Vactosertib (CAS No.: 1352608-82-2), is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM.. >99% Purity.
Synonyms: EW-7197, TEW-7197, EW7197, TEW7197,…
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Chemicals, Inhibitors, Activators, Antagonists, and AgonistsPRT-060318 (PRT318, P142–76)
$100.00 – $1,000.00PRT-060318 (PRT318, P142–76) (CAS No.: 1194961-19-7), a potent and selective inhibitor of spleen tyrosine kinase (Syk; IC50 = 4 nM). It is selective, inhibiting 92% of Syk activity, while…
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BLU-9931
$50.00 – $350.00BLU-9931 (CAS No.: 1538604-68-0), a potent, highly selective, and irreversible fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC50 of 3 nM and a Kd of 6 nM….
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Nazartinib (EGF-816)
$100.00 – $700.00Nazartinib (EGF-816) (CAS No.: 1508250-71-2), a covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min-1 on EGFR(L858R/790M) mutant, respectively. >98% Purity.
Synonyms: EGF-816, EGF816, EGFR…
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JNJ-4796
$800.00 – $8,000.00JNJ-4796 (CAS No.: 2241664-16-2), an oral active fusion inhibitor of influenza virus, neutralizing influenza A group 1 viruses by inhibiting hemagglutinin (HA)-mediated fusion. >98% Purity.
Synonyms: JNJ4796, fusion inhibitor,…
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Tirabrutinib (ONO-4059, GS-4059)
$50.00 – $400.00Tirabrutinib (ONO-4059, GS-4059) (CAS No.: 1351636-18-4), a selective and novel inhibitor of BTK with IC50 2.2 nM, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling…
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DEL-22379
$75.00 – $600.00DEL-22379 (CAS No.: 181223-80-3), a potent and selective ERK Dimerization inhibitor. DEL-22379 inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes. Nearly 50%…
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BEC hydrochloride
$80.00 – $600.00BEC hydrochloride (CAS No.: 222638-67-7), a slow-binding and competitive Arginase II inhibitor. >98% Purity.
Synonyms: BEC, BEC HCl, Arginase II inhibitor
For Research Use Only.
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Ozanimod (RPC-1063)
$80.00 – $550.00RPC-1063 (CAS No.: 11306760-87-1), a Potent and Selective S1P1 and S1P5 Receptor Agonist with EC50s of 410 pM and 11 nM in [35S]-GTPγS Binding, Respectively. >98% Purity.
Synonyms: Ozanimod, RPC1063,…
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RTA-408 (Omaveloxolone)
$90.00 – $600.00RTA-408 (CAS No.: 1474034-05-3), a Novel Synthetic Triterpenoid That Binds to Kelch-like ECH-associated Protein 1 (Keap1) and Attenuate Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Degradation. >99% Purity.
Synonyms: Omaveloxolone, Nuclear…
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ND-646
$220.00 – $1,500.00ND-646 (CAS No.: 1434639-57-2), an Orally Bioavailable and Steric Inhibitor of Acetyl-CoA Carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for Recombinant hACC1 and hACC2, Respectively. >99% Purity.
Synonyms:…
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Batefenterol (GSK-961081)
$120.00 – $700.00GSK-961081 (Batefenterol, TD-5959) (CAS No.: 743461-65-6), Novel Muscarinic Receptor Antagonist and β2
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