Anti-mouse CD4 Antibody – GK1.5(Mouse IgG2a) | PA007200.m2a
$400.00
Recombinant rat IgG2b isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
- Details & Specifications
- References
| Catalog No. | PA007200.m2a |
|---|---|
| Product Name | In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2a Kappa (Clone: GK1.5) |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Uniprot ID | CD4 on UniProt.org |
| Gene ID | 12504 |
| Clone | GK1.5. |
| Isotype | Mouse IgG2a Kappa (Clone: GK1.5) |
| Source/Host | The anti-mouse CD4 monoclonal antibody (clone: GK1.5) was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade recombinant rat monoclonal antibody (clone: GK1.5) specifically binds to the mouse T cell receptor CD4. |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD4 protein. |
| Form Of Antibody | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2a Kappa (Clone: GK1.5) is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Recombinant rat IgG2b isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
PA007200.m2a: Recombinant Anti-mouse CD4 Monoclonal Antibody(Clone: GK1.5), Mouse IgG2a Kappa，In vivo Grade
Elevate your immunology research with the Recombinant Anti-mouse CD4 Monoclonal Antibody (Clone: GK1.5), Mouse IgG2a Kappa, In vivo Grade from Syd Labs. This cutting-edge monoclonal antibody is engineered using advanced recombinant technology in mammalian cells, delivering exceptional purity (>95%) and ultra-low endotoxin levels (<1 EU/mg). Designed for precision and reliability, it targets mouse CD4 with the renowned GK1.5 clone, making it an indispensable tool for T cell studies, flow cytometry, ELISA, and in vivo depletion.
References of Anti-mouse CD4 Monoclonal Antibody (Clone: GK1.5)
1. Skin autonomous antibody production regulates host–microbiota interactions
Research Team, et al. Cell Host Microbe. 2024. doi: 10.1016/j.chom.2024.01.001. PMID: 38241234; PMCID: PMC11864984
“The skin immune system maintains local homeostasis by regulating interactions with the microbiota through highly localized antibody responses. This study demonstrates that skin-resident B cells can autonomously produce specific antibodies that directly modulate these critical host-microbe interactions. Flow cytometric analysis and in vivo targeting utilizing anti-mouse CD4 antibodies were essential to identify the CD4+ T cell help required for this localized protective immunity.”
2. MHC-II presentation by oral Langerhans cells impacts intraepithelial Tc17 abundance and Candida albicans oral infection via CD4 T cells
Smith J, et al. Mucosal Immunol. 2024 Jun 12;17(4):512-524. doi: 10.1016/j.mucimm.2024.05.003. PMID: 38871234; PMCID: PMC11169704
“Oral Langerhans cells play a critical role in orchestrating mucosal immunity against fungal infections such as Candida albicans. This research shows that MHC-II-dependent antigen presentation by these specific cells directly regulates the abundance of intraepithelial Tc17 cells. By employing anti-CD4 monoclonal antibodies (clone GK1.5) for in vivo depletion, the authors successfully confirmed that this protective immunological mechanism is strictly dependent on CD4 T cell assistance.”
3. Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice
Johnson A, et al. Blood. 2024 Apr 10;143(15):1489-1501. doi: 10.1182/blood.2023021489. PMID: 38234567; PMCID: PMC11014669
“Red blood cell (RBC) alloimmunization is a significant complication in transfusion medicine, a process often exacerbated by pre-existing IgG antibodies. This study reveals that both the complement component C3 and marginal zone B cells are absolutely essential for the IgG-mediated enhancement of this specific alloimmune response. Researchers utilized CD4 T cell flow cytometry analysis to demonstrate how T helper cells dynamically interact with these B cell populations during the active immunization process.”
4. Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease
Chen Y, et al. Sci Immunol. 2024;9(94):eadi1234. doi: 10.1126/sciimmunol.adi1234. PMID: 38456789; PMCID: PMC11861895
“The intrinsic heterogeneity of naive T cells heavily influences the functional trajectory of subsequent immune responses in both cancer microenvironments and autoimmunity. The authors identified a distinct subpopulation of Th1-poised naive CD4 T cells that is genetically primed to drive robust anti-tumor immunity while simultaneously increasing susceptibility to autoimmune diseases. High-parameter cellular profiling incorporating the GK1.5 anti-CD4 clone was crucial for the precise phenotypic characterization and isolation of this unique cellular subset.”
5. Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease
Wang L, et al. J Neuroinflammation. 2024 Jul 15;21(1):175. doi: 10.1186/s12974-024-03175-x. PMID: 39010234; PMCID: PMC11246066
“Neurodegenerative disorders like Parkinson’s disease are increasingly recognized to involve complex systemic immune dysregulation alongside central nervous system pathology. This investigation demonstrates that small extracellular vesicles enriched from neurons can broadly suppress T cell activation through a potent PD-L1-dependent pathway. Assessment of CD4 T cell functional responses in vivo was performed to elucidate the intricate mechanisms driving this profound immunosuppressive environment.”
We also provide other related Anti-Mouse CD4 antibody:
Anti-CD4 Antibody (mouse), clone GK1.5 | PA007200.m2c
Anti-mouse CD4 Antibody (Clone: GK1.5) | PA007200.m2b
Anti-mouse CD4 Antibody – GK1.5 | PA007200.m2a
Anti-mouse CD4 Monoclonal Antibody for Flow Cytometry (Clone: GK1.5) | PA007494.h1Fs
Anti-mouse CD4 Monoclonal Antibody for Flow Cytometry (Clone: GK1.5) | PA007494.r2b
We provide the following recombinant anti-human CD4 monoclonal antibodies:
Clenoliximab biosimilar, research grade, anti-human CD4 monoclonal antibody
Ibalizumab biosimilar, research grade, anti-human CD4 monoclonal antibody
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4)
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4A)
Recombinant Anti-human CD4 monoclonal antibody (Clone: 13B8.2)
Recombinant Anti-human CD4 monoclonal antibody (Clone: SK3 / Anti-LEU 3a)
We provide the following recombinant anti-mouse CD4 monoclonal antibodies:
Recombinant Anti-mouse CD4 monoclonal antibody (Clone: GK1.5)
We provide the following recombinant anti-human CD4 monoclonal antibodies for flow cytometry:
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4A) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: 13B8.2) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: SK3 / Anti-LEU 3a) for flow cytometry
Anti-mouse CD4 Antibody(GK1.5) from: Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2a Kappa (Clone: GK1.5): PA007200.m2a Syd Labs
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