Human IgG2 Fc Protein, In Vivo Grade Recombinant

Catalog No.	BP4092
Product Name	Human IgG2 Fc Protein, In Vivo Grade Recombinant
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	Human Fc protein (IgG2), Human IgG2 Fc region
Summary	The recombinant human IgG2 Fc protein was produced in HEK 293 cells and purified by protein A.
Form Of Antibody	0.2 µM filtered solution of 1x PBS.
Endotoxin	Less than 1 EU/mg of protein as determined by LAL method.
Purity	>95% by SDS-PAGE under reducing conditions
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Orleave a message with a formal purchase order (PO) Or credit card.

Description

BP4092: Human IgG2 Fc Protein, In Vivo Grade Recombinant

Background

Human Fc (IgG2) is the tail region of an immunoglobulin G2 (IgG2) that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. The ~230 amino acid fragment generally exists as a dimer, although under reducing conditions, it exists as a monomer. It is the basis of prolonged pharmacokinetics of antibodies and is commonly used as a fusion to extend half-life of fusion proteins. IgG2 has a shorter hinge than IgG1, with 12 amino acid residues and four disulfide bridges at the Fab base. The hinge region of IgG2 also lacks a glycine residue, which along with its shortness almost completely prevents rotation and restricts lateral movement of the Fabs.

The recombinant human IgG2 Fc protein was produced in HEK 293 cells and purified by protein A.

Other Recombinant IgG Fc Proteins:
Recombinant Human Fc Protein (hIgG2), In vivo Grade
Recombinant Human Fc Protein (hIgG4), In vivo Grade
Recombinant Mouse Fc Protein (mIgG1), In vivo Grade

Recombinant IgG Reference Antibodies:
Recombinant Human IgG1 Isotype Control Antibody and Mutants, In vivo Grade
Recombinant Human IgG2 Isotype Control Antibody, In vivo Grade
Recombinant Human IgG4-S228P Isotype Control Antibody and Mutants, In vivo Grade
Recombinant Mouse IgG1 Isotype Control Antibody and Mutants, In vivo Grade
Recombinant Mouse IgG2a Isotype Control Antibody and Mutants, In vivo Grade
Recombinant Mouse IgG2b Isotype Control Antibody and Mutants, In vivo Grade
Recombinant Mouse IgG2c Isotype Control Antibody and Mutants, In vivo Grade
Recombinant Rat IgG1 Isotype Control Antibody, In vivo Grade
Recombinant Rat IgG2a Isotype Control Antibody, In vivo Grade
Recombinant Rat IgG2b Isotype Control Antibody, In vivo Grade
Recombinant Rat IgG2c Isotype Control Antibody, In vivo Grade

Fc ELISA Kits and Reagents:
Human Fc ELISA Kit
Mouse Fc ELISA Kit
Human Fc ELISA Reagent Kit
Mouse Fc ELISA Reagent Kit

Protein A, Resin, Columns, and ELISA Kits:
Recombinant Protein A
Protein A Affinity Resin
Pre-packed Protein A Column
Protein A ELISA Kit

Please remember our product information: In Vivo Grade Recombinant Human IgG2 Fc Protein: BP4092 Syd Labs

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