Recombinant Anti-mouse CD28 Monoclonal Antibody (Clone 37.51), Human IgG1 Fc Silent Kappa PA007491.h1Fs Ushelf

Anti-mouse CD28 Antibody for Flow Cytometry | PA007491.h1Fs

Name: Anti-mouse CD28 Antibody for Flow Cytometry
Brand: Syd Labs
SKU: PA007491.h1Fs
Price: 30-60 USD
Availability: InStock
Rating: 5 (1 reviews)

$50.00 – $100.00

Recombinant Mouse IgG1 isotype controls and Recombinant Human IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.

Details & Specifications
References

Catalog No.	PA007491.h1Fs
Product Name	Recombinant Anti-mouse CD28 Monoclonal Antibody (Clone: 37.51), Human IgG1 Fc Silent Kappa
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	T-cell-specific surface glycoprotein CD28; TP44
Clone	37.51.
Isotype	Human IgG1 kappa.
Source/Host	The anti-mouse CD28 monoclonal antibody (clone: 37.51) for Flow Cytometry was produced in mammalian cells.
Specificity/Sensitivity	The recombinant 37.51 antibody for Flow Cytometry specifically binds to mouse CD28.
Applications	Flow cytometry (FC), and Immunohistochemistry - Frozen (IHC-F).
Form Of Antibody	0.2 uM filtered solution, pH 7.4, containing 0.09% sodium azide.
Conjugate	Non-conjugated.
Purity	>95% by SDS-PAGE under reducing conditions.
Shipping	The Recombinant Anti-mouse CD28 Monoclonal Antibody (Clone: 37.51) for Flow Cytometry, Human IgG1 Fc Silent Kappa is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, 2 to 8°C as supplied. Do not freeze it.
Note	Recombinant Human IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007491.h1Fs: Recombinant Anti-mouse CD28 Monoclonal Antibody (Clone: 37.51) for Flow Cytometry, Human IgG1 Fc Silent Kappa

Recombinant Human IgG1 Monoclonal Antibody with Fc silent mutation.

References of Anti-Mouse CD28 Monoclonal Antibody (Clone: 37.51)

1. Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition
Tokifuji Y, et al.iScience. 2023 Dec 9;27(1):108646. PMID: 38226171
“IL-17-producing helper T (Th17) cells are long-lived and serve as central effector cells in chronic autoimmune diseases. The underlying mechanisms of Th17 persistence remain unclear…”

2. A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex
Hong S, et al.Cell Commun Signal. 2024 Oct 30;22(1):526. PMID: 39478550
“Phospholipase C gamma 1 (PLCγ1) is an important mediator of the T cell receptor (TCR) and growth factor signaling. PLCγ1 is activated by Src family kinases (SFKs) and produces inositol 1,4,5-triphosphate (InsP3) from phosphatidylinositol 4,5-bisphosphate (PIP2)…”

3. Water channel aquaporin 4 is required for T cell receptor mediated lymphocyte activation
Nicosia M, et al.J Leukoc Biol. 2023 Jun 1;113(6):qiad010. PMID: 36805947
“Aquaporins are a family of ubiquitously expressed transmembrane water channels implicated in a broad range of physiological functions. We have previously reported that aquaporin 4 (AQP4) is expressed on T cells and that treatment with a small molecule AQP4 inhibitor significantly delays T cell mediated heart allograft rejection…”

4. SEL1L preserves CD8+ T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis
Gao Y, et al.Cell Mol Immunol. 2023 Oct;20(10):1232-1250. PMID: 37644166
“SEL1L-mediated endoplasmic reticulum-associated degradation (ERAD) plays critical roles in controlling protein homeostasis by degrading misfolded or terminal unfolded proteins. However, it remains unclear how SEL1L regulates peripheral T-cell survival and homeostasis…”

5. Sirtuin 5 is Dispensable for CD8+ T Cell Effector and Memory Differentiation
Duan Q, et al.Front Cell Dev Biol. 2021 Dec 13;9:761193. PMID: 34966740
“CD8+ T cell effector and memory differentiation is tightly controlled at multiple levels including transcriptional, metabolic, and epigenetic regulation. Sirtuin 5 (SIRT5) is a protein deacetylase mainly located at mitochondria, but it remains unclear whether SIRT5 plays key roles in regulating CD8+ T cell effector or memory formation…”

For more technical references or data sheets regarding the Recombinant Anti-Mouse CD28 Monoclonal Antibody (Clone: 37.51) formats, please contact our scientific support team at message@sydlabs.com or explore options via Syd Labs.