IRP2 Rabbit mAb
$148.00 – $548.00
ACO3; IRP2; IRP2AD; NDCAMA; IRE-BP2; IRE-BP 2
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| Catalog No. | A22283 |
|---|---|
| Product Name | IRP2 Rabbit mAb |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Synonyms | ACO3; IRP2; IRP2AD; NDCAMA; IRE-BP2; IRE-BP 2 |
| Gene Name | IREB2 |
| Protein Name | IREB2 |
| Uniprot/Swissprot ID | P48200 |
| Gene ID | 3658 |
| Clone | ARC55070 |
| Clonality | Monoclonal |
| Source/Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Conjugate | Unconjugated |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5′ or 3′ UTRs. Binding to the 5′ UTR represses translation, while binding to the 3′ UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms.
