ABflo® 647 Rabbit anti-Human CD40 mAb (A21947)

ABflo® 647 Rabbit anti-Human CD40 mAb (A21947)

ABflo® 647 Rabbit anti-Human CD40 mAb (A21947)

$218.00$568.00

In stock

$218.00$568.00

Abclonal ABflo® 647 Rabbit anti-Human CD40 mAb (Catalog Number: A21947) is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

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Catalog No. A21947
Product NameABflo® 647 Rabbit anti-Human CD40 mAb (A21947)
Supplier Name ABclonal, Inc.
Brand Name Abclonal
Synonyms p50; Bp50; CDW40; TNFRSF5
Gene Name CD40
Protein Name CD40
Uniprot/Swissprot ID P25942
Entrez GeneID 958
Clonality Monoclonal
Source/Host Rabbit
Applications FC
Reactivity Human
Conjugate ABflo® 647. Ex:656nm. Em:670nm.
Note Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

A21947: ABflo® 647 Rabbit anti-Human CD40 mAb

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Immunogen Information about ABflo® 647 Rabbit anti-Human CD40 mAb (A21947)

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-193 of human CD40 (P25942).
Sequence:EPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLR
Gene ID:958
Swiss prot:P25942
Synonyms:p50; Bp50; CDW40; TNFRSF5
Calculated MW:31kDa
Observed MW:Refer to figures

Images of ABflo® 647 Rabbit anti-Human CD40 mAb (A21947)

Flow cytometry:1X10^6 Jurkat cells (negative control, left) and Raji cells (right) were surface-stained with ABflo® 647 Rabbit anti-Human CD40 mAb(A21947, 5 μl/Test, orange line) or ABflo® 647 Rabbit IgG isotype control (A22070, 5 μl/Test, blue line). Non-fluorescently stained cells were used as blank control (red line).

Please remember our product information: ABflo® 647 Rabbit anti-Human CD40 mAb (Catalog Number: A21947) Abclonal

Additional information

Ship from Country

USA

Size

100 μg, 25 μg, 50 μg

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