Cetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant

Cetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant

$375.00

In stock

$375.00

Cetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant. The research grade cetuximab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Cetuximab biosimilar CHO stable cell line is available for licensing to manufacture the cetuximab biosimilar protein.

SKU: C002P.LA
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Catalog No. C002P.LA
Product NameCetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Supplier Name Syd Labs, Inc.
Brand Name Syd Labs
Synonyms Anti-EGFR Chimeric Monoclonal Antibody
Summary Recombinant Chimeric IgG1 Monoclonal Antibody.
Isotype Human IgG1 kappa.
Source/Host The monoclonal antibody cetuximab biosimilar was produced in the cetuximab biosimilar CHO stable cell line.
Specificity/Sensitivity The monoclonal antibody cetuximab biosimilar specifically binds to the human EGFR.
Form Of Antibody 0.2 uM filtered solution, pH 7.2, no stabilizers or preservatives.
Endotoxin < 1 EU per 1 mg of the protein by the LAL method.
Purity >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping The Cetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note The research grade cetuximab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Cetuximab biosimilar CHO stable cell line is available for licensing to manufacture the cetuximab biosimilar protein.
Order Offline Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Orleave a message with a formal purchase order (PO) Or credit card.

Description

C002P.LA: Cetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant

Recombinant Chimeric IgG1 Monoclonal Antibody.

Background

Cetuximab, a chimeric (mouse/human) anti-EGFR monoclonal antibody, is an EGFR inhibitor used for the treatment of metastatic colorectal cancer and head and neck cancer. Cetuximab binds to EGFR and turns off the uncontrolled growth in cancers with EGFR mutations.

Cetuximab can be used for treatment of KRAS wild type colon cancer but has little or no effect in colorectal tumors harboring a KRAS mutation. Before treatment using Erbitux, it is better to do a diagnosis using the real time PCR companion diagnostic test for KRAS, the therascreen KRAS test.

There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1; HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, EGFR (epidermal growth factor receptor) located on cell surface sends a signal down the MAPK pathway that includes another protein, KRAS (also spelled K-ras). Mutations affecting EGFR and/or KRAS expression or activity could result in cancer. The mutated KRAS continuously sends a growth signal to the downstream pathway, leading to uncontrollable cell division, even if EGFR has been blocked.

Syd Labs also provides the following anti-ErbB/HER antibody biosimilars:
Panitumumab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Trastuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Pertuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)

Syd Labs also provides the following research grade antibody biosimilar proteins:
Bevacizumab Biosimilar, research grade (VEGF-A)
Ranibizumab Biosimilar, research grade (VEGF-A, Fab produced in E. coli)
Cetuximab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Panitumumab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Trastuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Pertuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Infliximab biosimilar, research grade (TNF alpha)
Adalimumab biosimilar, research grade (TNF alpha)
Rituximab biosimilar, research grade (CD20)
Denosumab biosimilar, research grade (RANKL, RANK ligand, OPGL, TNFSF11, CD254, TRANCE, ODF)
Palivizumab Biosimilar, research grade (RSV)
Omalizumab biosimilar, research grade (IgE)
Eculizumab biosimilar, research grade (C5)

Syd Labs provides the following research grade antibody biosimilars used in ADCs:
Tusamitamab biosimilar, research grade, anti-human CEACAM5 monoclonal antibody
Rovalpituzumab biosimilar, research grade, anti-human DLL3 monoclonal antibody
Trastuzumab biosimilar, research grade, anti-human HER2 monoclonal antibody
Cofetuzumab biosimilar, research grade, anti-human PTK7 monoclonal antibody
Ifinatamab biosimilar, research grade, anti-human B7-H3 (CD276) monoclonal antibody
Sacituzumab biosimilar, research grade, anti-human Trop-2 monoclonal antibody
Gemtuzumab biosimilar, research grade, anti-human CD33 monoclonal antibody
Polatuzumab biosimilar, research grade, anti-human CD79B monoclonal antibody
Cetuximab biosimilar, research grade, anti-human EGFR monoclonal antibody

Please remember our product information: Cetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant: C002P.LA Syd Labs

Additional information

Ship from Country

USA

Size

0.5 mg

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