Gemtuzumab Biosimilar, Anti-human CD33 Monoclonal Antibody

Gemtuzumab Biosimilar, Anti-human CD33 Monoclonal Antibody

$250.00$2,000.00

In stock

$250.00$2,000.00

Gemtuzumab Biosimilar, CD33 Monoclonal Antibody. The research grade Gemtuzumab biosimilar protein is for research use only (RUO). Recombinant human IgG4 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.

SKU: C049P
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Catalog No. C049P
Product NameGemtuzumab Biosimilar, Anti-human CD33 Monoclonal Antibody
Supplier Name Syd Labs, Inc.
Brand Name Syd Labs
Synonyms Siglec-3, sialic acid binding Ig-like lectin 3, SIGLEC3, gp67, p67
Summary Recombinant Humanized IgG4 Monoclonal Antibody.
Source/Host The anti-human CD33 monoclonal antibody gemtuzumab biosimilar was produced in the gemtuzumab biosimilar CHO stable cell line.
Specificity/Sensitivity The in vivo grade gemtuzumab biosimilar specifically binds to the human CD33 protein.
Applications ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by gemtuzumab.
Form Of Antibody 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin < 1 EU per 1 mg of the protein by the LAL method.
Purity >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping The research grade gemtuzumab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note The research grade Gemtuzumab biosimilar protein is for research use only (RUO). Recombinant human IgG4 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Orleave a message with a formal purchase order (PO) Or credit card.

Description

C049P: Gemtuzumab Biosimilar, Anti-human CD33 Monoclonal Antibody

Recombinant Humanized IgG4 Monoclonal Antibody.

Background

Gemtuzumab is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheamicin per mole of antibody Label. The antibody is specifically directed against the CD33 antigen present on leukemic myeloblasts in most patients with acute myeloid leukemia (AML). By binding to the CD33 antigen on tumors, the cytotoxic agent blocks the growth of cancerous cells and causes cell death.

Gemtuzumab is directed against the CD33 antigen expressed by hematopoietic cells. Binding of the anti-CD33 antibody portion of Gemtuzumab with the CD33 antigen results in the formation of a complex that is internalized. Upon internalization, the calicheamicin derivative is released inside the lysosomes of the myeloid cell. The released calicheamicin derivative binds to DNA in the minor groove resulting in site-specific DNA double strand breaks via formation of a p-benzene diradical. Eventually, cell death is induced.

Syd Labs provides the following research grade antibody biosimilars used in ADCs:
Tusamitamab biosimilar, research grade, anti-human CEACAM5 monoclonal antibody
Rovalpituzumab biosimilar, research grade, anti-human DLL3 monoclonal antibody
Trastuzumab biosimilar, research grade, anti-human HER2 monoclonal antibody
Cofetuzumab biosimilar, research grade, anti-human PTK7 monoclonal antibody
Ifinatamab biosimilar, research grade, anti-human B7-H3 (CD276) monoclonal antibody
Sacituzumab biosimilar, research grade, anti-human Trop-2 monoclonal antibody
Gemtuzumab biosimilar, research grade, anti-human CD33 monoclonal antibody
Polatuzumab biosimilar, research grade, anti-human CD79B monoclonal antibody
Cetuximab biosimilar, research grade, anti-human EGFR monoclonal antibody
CD33

Please remember our product information: Gemtuzumab Biosimilar, CD33 Monoclonal Antibody: C049P Syd Labs

Additional information

Size

1 mg, 20 mg, 5 mg

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