Mouse IgG2c-LALAPG Isotype Control Antibody | PA007141

Name: Mouse IgG2c-LALAPG Isotype Control Antibody (12B9)
Brand: Syd Labs
SKU: PA007141
Price: 150-800 USD
Availability: InStock
Rating: 5 (1 reviews)

$150.00 – $800.00

Recombinant mouse IgG2c kappa isotype control and Fc silenced mutant, mIgG2c LALAPG, good for in vitro and in vivo studies. Low or no specific binding to mouse samples tested. More choices of recombinant mouse IgG2c isotype controls, including targets, mutants, tags, and conjagates.

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Syd Labs, Inc.

SKU: PA007141 Categories: Antibodies, Antibody Isotype Controls Tags: Mouse IgG2c Isotype Control, Mouse IgG2c Isotype Control Antibody, mouse igg2c-lalapg isotype control

Details & Specifications
References

Catalog No.	PA007141
Product Name	Mouse IgG2c-LALAPG Isotype Control Antibody \| PA007141
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	mIgG2c Isotype Control, Mouse IgG2c LALAPG Isotype Control Mutant
Summary	The In Vivo Grade Recombinant Mouse IgG2c-L234A L235A P329G (LALAPG) Isotype Control Antibody was produced in mammalian cells.
Clone	12B9
Isotype	mouse IgG2c, kappa
Applications	an isotype-matched negative control for mouse IgG2c LALAPG kappa antibodies used in ELISA, Western Blot (WB), Flow Cytometry (Flow), Immunoprecipitation (IP), Immunohistochemistry (Paraffin) (IHC (P)), Immunohistochemistry (Frozen) (IHC (F)), and in vivo animal model research.
Immunogen	N/A.
Form Of Antibody	0.2 μM filtered solution of 1x PBS.
Endotoxin	Less than 1 EU/mg of protein as determined by LAL method.
Purity	>95% by SDS-PAGE under reducing conditions.
Shipping	Mouse IgG2c-LALAPG Isotype Control Antibody (12B9) is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 1 month from date of receipt, 2 to 8°C as supplied. 3 months from date of receipt, -20°C to -70°C as supplied.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007141: Recombinant Mouse IgG2c-L234A L235A P329G (LALAPG) Isotype Control Antibody (Clone: 12B9), In Vivo Grade

The Mouse IgG2c-L234A L235A P329G (LALAPG) Isotype Control Antibody is an essential tool designed for researchers in immunology and molecular biology. This antibody acts as a highly effective negative control in a variety of immunological assays, ensuring the precision and reliability of experimental outcomes. By incorporating this isotype control, scientists can accurately evaluate non-specific binding and background noise, which is critical for validating the performance of primary antibodies in their studies.

This Fc-silenced antibody features specific mutations—L234A, L235A, and P329G—collectively referred to as the LALAPG modifications, located in the Fc region. These alterations eliminate the antibody’s ability to interact with Fc receptors and trigger the complement system, ensuring no effector functions are activated. The Mouse IgG2c-LALAPG Isotype Control is thus an optimal choice for distinguishing specific antibody binding from non-specific interactions, providing researchers with clear and dependable results.

Syd Labs’s recombinant mouse IgG2c-L234A L235A P329G (mIgG2c LALAPG, Fc silenced) isotype control antibody (mIgG2c LALAPG isotype control) was produced in mammalian cells. Versatile and reliable, the Mouse IgG2c-LALAPG Isotype Control Antibody is suitable for numerous applications, including flow cytometry, immunohistochemistry, immunofluorescence, Western blotting, and ELISA. For best results, it should be used at the same concentration as the primary antibody to ensure accurate data interpretation. This mouse IgG2c isotype control is a must-have for any researcher aiming to enhance the credibility of their immunological experiments. Learn more about this product on our website or reach out to our support team for additional details.

Citations of Syd Labs Mouse IgG2c-LALAPG Isotype Control Antibody:

1、Lymphatic pumping technique in mice alters blood parameters and metastatic melanoma in an age-dependent manner
Kopchick JJ,et al.Exp Biol Med (Maywood). 2026 Mar 30;251:10850. doi: 10.3389/ebm.2026.10850. PMID: 41982211; PMCID: PMC13071501.
“The experimental design of the four in vivo experiments reported in this study is shown in …… In addition to the sham and LPT treatments, the mice were treated with anti-mouse programmed cell death protein 1 (PD1) antibody (#PA007163.m2cLA, Syd Labs) or an isotype control antibody (#PA007141, Syd Labs). Four treatments of 200 μg of antibody diluted in 100 μL of PBS (2 mg/mL) were administered intraperitoneally between days 9 and 21 of the experiment. The anti-PD1 dosing regimen of 200 ug per injection was selected based on established murine immunotherapy protocols rather than allometric scaling from human doses, consistent with prior studies demonstrating biological efficacy at this dose [21, 22]. Mice were divided into four treatment groups: group 1 received sham treatment and isotype control antibodies; group 2 received LPT and isotype control antibodies; group 3 received sham treatment and anti-PD1 antibodies; and group 4 received LPT treatment and anti-PD1 antibodies. The cancer cells were injected on experimental day 0, treatments started on day 8, ended on day 22, and the mice were euthanized with carbon dioxide inhalation and on day 25.”

Fc ELISA Kits and Reagents:
Human Fc ELISA Kit
Mouse Fc ELISA Kit
Human Fc ELISA Reagent Kit
Mouse Fc ELISA Reagent Kit

Mouse IgG2c-LALAPG Isotype Control (12B9) from: In Vivo Grade Recombinant Mouse IgG2c-L234A L235A P329G (LALAPG) Isotype Control Antibody: PA007141 Syd Labs

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Size	1 mg 25 mg 5 mg Clear

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Mouse IgG2c-LALAPG Isotype Control Antibody | PA007141

Mouse IgG2c-LALAPG Isotype Control Antibody | PA007141