Pan Acetyl-Lysine Mouse mAb

Catalog No.	A1525
Product Name	Pan Acetyl-Lysine Mouse mAb
Supplier Name	ABclonal, Inc.
Brand Name	Abclonal
Gene Name	pan Acetyl-K
Protein Name	pan Acetyl-K
Clonality	Monoclonal
Source/Host	Mouse
Applications	WB
Reactivity	Human, Mouse, Rat, Other (Wide Range)
Conjugate	Unconjugated
Note	Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline	Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

Acetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (PMID: 9667866). Signaling resulting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis (PMID: 14593721). Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of post-translational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport (PMID: 19608861). The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases (PMID: 11864588), and HDACs have become promising targets for anti-cancer drugs currently in development (PMID: 15032670).

Additional information

Ship from Country	USA
Size	100 ul, 200 ul, 50 ul

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