Search Results - what is the mechanism

Etoposide phosphate (BMY-40481)

Etoposide Phosphate (BMY-40481) (CAS No.: 117091-64-2), potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Synonyms: topoisomerase II inhibitor, BMY-40481, BMY40481, BMY 40481 For Research Use Only.

Glumetinib (SCC244)

Glumetinib (SCC244) is a highly selective, orally bioavailable, ATP-competitive c-Met inhibitor with an IC50 of 0.42 nM. Glumetinib has greater than 2400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member...

KB-0742 dihydrochloride (KB0742)

KB0742 (KB-0742, KB 0742) (CAS No.: 2416874-75-2), an orally bioavailable, potent and selective CDK9 inhibitor with an IC50 of 6 nM, highly selective against other CDKs (>60 fold). 99% Chem and Optical Purity. Synonyms: KB-0742, KB 0742,...

GSK046 (GSK-046, IBET-BD2)

GSK046 (iBET-BD2, GSK 046, GSK-046) (CAS No.: 2474876-09-8), a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4...

BI-3406

BI-3406 (CAS No.: 2230836-55-0), a highly potent, selective, and orally bioavailable inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. Synonyms: KRAS and Son of Sevenless 1...

Giredestrant (GDC-9545)

Giredestrant (GDC-9545, CAS No.: 1953133-47-5), an orally active and selective estrogen receptor antagonist, potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Synonyms: selective estrogen receptor degrader...