Anti-human CD3e Monoclonal Antibody (Clone: OKT3) | PA007203.m2a

Catalog No.	PA007203.m2a
Product Name	Anti-human CD3e Monoclonal Antibody (Clone: OKT3) | PA007203.m2a
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	cluster of differentiation 3, CD3D, CD3E, CD3G
Clone	OKT3 or OKT-3.
Isotype	Mouse IgG2a kappa.
Source/Host	The anti-human CD3 monoclonal antibody (clone: OKT3) was produced in mammalian cells.
Specificity/Sensitivity	The recombinant mouse monoclonal antibody (clone: OKT3) specifically binds to the human T cell receptor CD3.
Applications	Flow cytometry (FC), and Immunohistochemistry - Frozen (IHC-F).
Form Of Antibody	0.2 uM filtered solution, pH 7.4, containing 0.09% sodium azide.
Endotoxin	Less than 1 EU/mg of protein as determined by LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The Non-conjugated Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3) is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, 2 to 8°C as supplied. Do not freeze it.
Note	Recombinant mouse IgG2a isotype control is available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007203.m2a: Non-conjugated Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)

Recombinant mouse IgG2a Monoclonal Antibody.
Syd Labs provides the following recombinant anti-human CD3 monoclonal antibodies for flow cytometry:
Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
Biotin Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
FITC Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
APC Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
PE Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
Pacific Blue Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
PerCP Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
PE/Cy5 Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
PE/Cy7 Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
iFluor 488 Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
iFluor 549 Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
iFluor 594 Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
iFluor 647 Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
iFluor 700 Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
APC/Cy7 Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)
PerCP/Cy5.5 Recombinant Anti-human CD3e Monoclonal Antibody (Clone: OKT3)

Background:

The OKT3 antibody binds to CD3 epsilon of the T cell receptor-CD3 complex found only on mature T cells and medullary thymocytes. An interaction between T cells, OKT3, and monocytes causes T-cell activation (mitogenesis) in vitro. On the other hand, the OKT3 antibody blocks the unique association between the antigen receptor and CD3, and both the generation and function of cytotoxic T cells. After an initial dose of the OKT3 antibody, T cells disappear from the circulation within minutes to hours. During treatment with the OKT3 antibody, T cells bearing the usual array of surface molecules (CD2, CD4, and CD8) reappear in the peripheral blood circulation but these cells are devoid of CD3. After another 48 hours without the OKT3 antibody, the normal array of surface molecules including CD3 appear again on all T cells. The selective removal of CD3 by internalization is thought to be the key mechanism of action of the OKT3 antibody. Comodulation of the antigen receptor with CD3 explains the immunoblocking action of the OKT3 antibody in vivo. The OKT3 antibody is ineffective clinically if the CD3 target molecule is not modulated.

The OKT3 antibody is effective for induction of immunosuppression and for treating initial and steroid-resistant rejections.

Syd Labs provides the following recombinant anti-mouse CD3 monoclonal antibodies for flow cytometry:

Recombinant Anti-mouse CD3 monoclonal antibody (Clone: 17A2) for flow cytometry
Recombinant Anti-mouse CD3e monoclonal antibody (Clone: 145-2C11) for flow cytometry

Syd Labs provides the following recombinant anti-human CD3 monoclonal antibodies for flow cytometry:

Recombinant Anti-human CD3 monoclonal antibody (Clone: OKT3) for flow cytometry
Recombinant Anti-human CD3 monoclonal antibody (Clone: UCHT1) for flow cytometry
Recombinant Anti-human CD3 monoclonal antibody (Clone: 12F6) for flow cytometry
Recombinant Anti-human CD3 monoclonal antibody (Clone: SP34-2) for flow cytometry

Syd Labs provides the following in vivo grade recombinant anti-human CD3 monoclonal antibodies:

Muromonab biosimilar, research grade, anti-human CD3 monoclonal antibody (Clone: OKT3)
Teplizumab biosimilar, research grade, anti-human CD3 monoclonal antibody (Clone: OKT3)
Foralumab biosimilar, research grade, anti-human CD3 monoclonal antibody (Clone: OKT3)
Recombinant Anti-human CD3 monoclonal antibody (Clone: OKT3)
Recombinant Anti-human CD3 monoclonal antibody (Clone: SP34-2)
Recombinant Anti-human CD3 monoclonal antibody (Clone: UCHT1)
Recombinant Anti-human CD3 monoclonal antibody (Clone: 12F6)

Syd Labs provides the following in vivo grade recombinant anti-mouse CD3 monoclonal antibodies:

Recombinant Anti-mouse CD3e monoclonal antibody (Clone: 145-2C11)
Recombinant Anti-mouse CD3e monoclonal antibody (Clone: 500A2)
Recombinant Anti-mouse CD3 monoclonal antibody (Clone: 17A2)

Anti-human CD3e Monoclonal Antibody (Clone: OKT3) from: Anti-human CD3e Monoclonal Antibody (Clone: OKT3): PA007203.m2a Syd Labs

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