Satumomab Biosimilar, Anti-human TAG-72 Monoclonal Antibody
$175.00 – $1,200.00
The cheapest research grade satumomab biosimilar (anti-human TAG-72 monoclonal antibody, mAb) for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by satumomab. The research grade satumomab biosimilar protein is for research use only.
Synonyms: tumor-associated glycoprotein 72, TAG72
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| Catalog No. | C064P |
|---|---|
| Product Name | Satumomab Biosimilar, Anti-human TAG-72 Monoclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Source/Host | The anti-human TAG-72 monoclonal antibody satumomab biosimilar was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade satumomab biosimilar specifically binds to the human tumor-associated glycoprotein TAG-72. |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by satumomab. |
| Form Of Antibody | 0.2 uM filtered solution, pH 6.0, no stabilizers or preservatives. |
| Endotoxin | < 0.1 EU per 1 ug of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The research grade satumomab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
C064P: Satumomab Biosimilar (Research Grade), Anti-human TAG-72 Monoclonal Antibody
Recombinant Humanized IgG1 Monoclonal Antibody.
Background
Satumomab Biosimilar uses the same protein sequences as the therapeutic antibody satumomab.
Satumomab is a modified mouse monoclonal antibody which could specifically bind to tumor-associated glycoprotein (TAG-72). Satumomab is usually combined with some radioactive elements to diagnose colorectal cancer and ovarian cancer. Satumomab is also used to study the distribution of tumor cell-associated antigens in breast cancer. The original satumomab monoclonal antibody was produced by purifying the membrane enrichment part of human breast cancer biopsy tissue and immunizing mice. In fact, in addition to colorectal and ovarian cancer, satumomab can also interact with a variety of cancer cells, including gastric cancer, pancreatic cancer, endometrial cancer and lung adenocarcinoma. For a variety of normal adult tissues, except secretory endometrium, B72.3 had no effect or only weak response.
The characteristic that satumomab can bind to tumor antigen TAG-72 has been used in the clinical study of various cancer detection. Serological tests used satumomab showed that 50% of cancer patients could be detected TAG-72 and 4% of the control population could be detected TAG-72. Satumomab is also used to detect embryonic carcinoma and fine needle biopsy in human effusion and as a diagnostic tool to distinguish lung adenocarcinoma from non-small cell lung cancer or malignant mesothelioma. Labeled satumomab-assisted computer scanning is used to study the localization of tumor lesions. The target of satumomab, TAG-72, is a kind of tumor marker with high specificity and few false positive. Because TAG-72 widely exists in all kinds of cancer tissues and has little expression in normal and benign lesions, anti-TAG-72 monoclonal antibody, which uses satumomab as substitute, has been applied to the study of immunohistochemistry and immunocytochemistry. Those monoclonal antibodies have become a useful tool for clinical tumor diagnosis and differential diagnosis.
Syd Labs also provides the following anti-TAG-72 antibody biosimilar proteins:
Minretumomab Biosimilar, research grade, anti-human TAG-72 monoclonal antibody
Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg. Syd Labs also introduces mutations to the antibody biosimilars including engineering or switching the isotypes or Fc engineering, such as Fc silent.
Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls. Syd Labs provides the following in vivo grade recombinant human IgG1 kappa isotype control antibody proteins and mutants:
In vivo grade recombinant human IgG1 isotype control antibody
In vivo grade recombinant human IgG1 Fc protein
In vivo grade recombinant human IgG1-D265A isotype control antibody
In vivo grade recombinant human IgG1-N297A isotype control antibody
In vivo grade recombinant human IgG1-D265A N297A isotype control antibody
In vivo grade recombinant human IgG1-L234A L235A P329G (LALAPG) isotype control antibody
Frequent questions related to “research grade satumomab biosimilar, anti-human TAG-72 monoclonal antibody”:
Does satumomab bind mouse TAG-72?
Is satumomab humanized?
What is the mechanism of action for satumomab?
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Satumomab Biosimilar Research Grade
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Additional information
| Size | 1 mg, 20 mg, 5 mg |
|---|