Toralizumab Biosimilar, Anti-human CD40L Monoclonal Antibody

Catalog No.	C066P
Product Name	Toralizumab Biosimilar, Anti-human CD40L Monoclonal Antibody
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Source/Host	The anti-human CD40L monoclonal antibody toralizumab biosimilar was produced in mammalian cells.
Specificity/Sensitivity	The in vivo grade toralizumab biosimilar specifically binds to the human CD40L / CD154 protein.
Applications	ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by toralizumab.
Form Of Antibody	0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin	< 0.1 EU per 1 ug of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The research grade toralizumab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

C066P: Toralizumab Biosimilar (Research Grade), Anti-human CD40L Monoclonal Antibody

Recombinant Humanized IgG1 Monoclonal Antibody.

Background

Toralizumab Biosimilar uses the same protein sequences as the therapeutic antibody toralizumab.

Toralizumab is a humanized (from mouse) monoclonal antibody and expressed in CHO binding to human CD40 ligand, as well as an immunosuppressive drug. Its possible indications included treatment of antibody-mediated disorders (immune thrombocytopenic purpura, lupus nephritis, rheumatoid arthritis), T-cell-mediated diseases (multiple sclerosis, Crohn’s disease, and transplantations such as solid organ transplantation, pancreatic islet cell transplantation, and corneal transplantation), and B-cell malignancies such as CLL/small lymphocytic lymphoma, follicular cell lymphoma grade I or II, marginal zone lymphoma, mantle cell lymphoma, MALT lymphoma, Waldenstrom’s macroglobulinemia, monocytoid B-cell lymphoma; relapsed/refractory Hodgkin’s disease).

Systemic lupus erythematosus (SLE) is a multisystem and complex autoimmune disease that results in morbidity, an increased mortality rate and a poor quality of life. At the same time, modern allotransplantation requires the daily administration of nonspecific immunosuppressive agents to prevent T cell-mediated acute rejection. The CD40 ligand (CD40L, also known as CD154) has been shown to be an important modulator of immunoinflammatory events in autoimmune disease and acute allograft rejection. The CD40 ligand (CD40L, also known as CD154) has been shown to be an important modulator of immunoinflammatory events in autoimmune disease and acute allograft rejection. CD40 is expressed constitutively on antigen presenting cells (APCs), including B cells, while CD40L is a member of the tumor necrosis factor family of transmembrane glycoproteins and is expressed on activated CD4þ T cells. The CD40-CD40L interaction is essential for normal T cell–B-cell interactions, including T-cell priming, immunoglobulin (Ig) class-switching, and the T cell-dependent humoral immune response. Indeed, the CD40-CD40L molecules form a co-stimulatory pair, providing the second signal required for T-cell activation of APCs. CD154 binds to CD40 and leads to APC secretion of IL-1β, TNF-α, and IL-12, and to endothelial cell secretion of monocyte chemotactic factors. It also increases APC and endothelial cell expression of MHC class II molecules, of adhesion molecules, and of the co-stimulatory ligands CD80 and CD86. Although blockade of the CD154-CD40 pathway does little to prevent the proliferative response of CD4+ T cells in vitro, it substantially curtails the maturation of cytotoxic CD8+ T cells by interfering with required T-cell-APC interactions. The monoclonal antibody, toralizumab, blocks CD40L binding to CD40 and inhibits T-cell-dependent B-cell proliferation and differentiation. As the Fab’ fragment of toralizumab shows activity similar to the intact IgG molecule, it is believed that CD40-CD40L blockade is the principal behind the therapeutic activity seen in this antibody. The effects of anti-CD154 mAb on activated T cells, endothelial cells, and APCs are believed to mediate the allograft-promoting effect. Toralizumab has been studied in clinical trials, but it also has been limited by thrombotic complications seen in early human trials, similar to ruplizumab.

Syd Labs also provides the following anti-CD40L antibody biosimilar proteins:
Ruplizumab Biosimilar, research grade, anti-human CD40L / CD154 monoclonal antibody

Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg. Syd Labs also introduces mutations to the antibody biosimilars including engineering or switching the isotypes or Fc engineering, such as Fc silent.

Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls. Syd Labs provides the following in vivo grade recombinant human IgG1 kappa isotype control antibody proteins and mutants:

In vivo grade recombinant human IgG1 isotype control antibody
In vivo grade recombinant human IgG1 Fc protein
In vivo grade recombinant human IgG1-D265A isotype control antibody
In vivo grade recombinant human IgG1-N297A isotype control antibody
In vivo grade recombinant human IgG1-D265A N297A isotype control antibody
In vivo grade recombinant human IgG1-L234A L235A P329G (LALAPG) isotype control antibody

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Additional information

Size	1 mg, 20 mg, 5 mg

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