PRT-060318 (PRT318, P142–76) (CAS No.: 1194961-19-7), a potent and selective inhibitor of spleen tyrosine kinase (Syk; IC50 = 4 nM). It is selective, inhibiting 92% of Syk activity, while other kinases retain >70% activity, at...
BLU-9931 (CAS No.: 1538604-68-0), a potent, highly selective, and irreversible fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC50 of 3 nM and a Kd of 6 nM. BLU-9931 has significant antitumor activity. >98%...
Nazartinib (EGF-816) (CAS No.: 1508250-71-2), a covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min-1 on EGFR(L858R/790M) mutant, respectively. >98% Purity. Synonyms: EGF-816, EGF816, EGFR inhibitor, epidermal growth factor receptor inhibitor For...
JNJ-4796 (CAS No.: 2241664-16-2), an oral active fusion inhibitor of influenza virus, neutralizing influenza A group 1 viruses by inhibiting hemagglutinin (HA)-mediated fusion. >98% Purity. Synonyms: JNJ4796, fusion inhibitor, influenza virus inhibitor For Research Use Only.
Tirabrutinib (ONO-4059, GS-4059) (CAS No.: 1351636-18-4), a selective and novel inhibitor of BTK with IC50 2.2 nM, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development. >98% Purity. Synonyms:...
DEL-22379 (CAS No.: 181223-80-3), a potent and selective ERK Dimerization inhibitor. DEL-22379 inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes. Nearly 50% of human malignancies exhibit unregulated RAS-ERK...
BEC hydrochloride (CAS No.: 222638-67-7), a slow-binding and competitive Arginase II inhibitor. >98% Purity. Synonyms: BEC, BEC HCl, Arginase II inhibitor For Research Use Only.
RPC-1063 (CAS No.: 11306760-87-1), a Potent and Selective S1P1 and S1P5 Receptor Agonist with EC50s of 410 pM and 11 nM in [35S]-GTPγS Binding, Respectively. >98% Purity. Synonyms: Ozanimod, RPC1063, sphingosine-1-phosphate receptor subtypes 1, sphingosine-1-phosphate receptor...
RTA-408 (CAS No.: 1474034-05-3), a Novel Synthetic Triterpenoid That Binds to Kelch-like ECH-associated Protein 1 (Keap1) and Attenuate Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Degradation. >99% Purity. Synonyms: Omaveloxolone, Nuclear Factor Erythroid 2-Related Factor 2, Nrf2,...
ND-646 (CAS No.: 1434639-57-2), an Orally Bioavailable and Steric Inhibitor of Acetyl-CoA Carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for Recombinant hACC1 and hACC2, Respectively. >99% Purity. Synonyms: Acetyl-CoA Carboxylase, ACC For Research Use Only.
