Search Results - NES

Vactosertib (EW-7197, TEW-7197)

Vactosertib (CAS No.: 1352608-82-2), is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM.. >99% Purity. Synonyms: EW-7197, TEW-7197, EW7197, TEW7197, ALK5 inhibitor, ATP-competitive activin receptor-like kinase...

PRT-060318 (PRT318, P142–76)

PRT-060318 (PRT318, P142–76) (CAS No.: 1194961-19-7), a potent and selective inhibitor of spleen tyrosine kinase (Syk; IC50 = 4 nM). It is selective, inhibiting 92% of Syk activity, while other kinases retain >70% activity, at...

BLU-9931

BLU-9931 (CAS No.: 1538604-68-0), a potent, highly selective, and irreversible fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC50 of 3 nM and a Kd of 6 nM. BLU-9931 has significant antitumor activity. >98%...

Nazartinib (EGF-816)

Nazartinib (EGF-816) (CAS No.: 1508250-71-2), a covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min-1 on EGFR(L858R/790M) mutant, respectively. >98% Purity. Synonyms: EGF-816, EGF816, EGFR inhibitor, epidermal growth factor receptor inhibitor For...