Tocilizumab Biosimilar, Anti-human IL-6R Monoclonal Antibody | C032P

Catalog No.	C032P
Product Name	Tocilizumab Biosimilar, Anti-human IL-6R Monoclonal Antibody | C032P
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	Interleukin 6, IL-6, IL6, BSF2, HGF, HSF, IFNB2, BSF-2, CDF, IFN-beta-2, Interleukin 6 receptor, CD126, Cluster of Differentiation 126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80
Summary	Recombinant Humanized IgG1 Monoclonal Antibody.
Source/Host	The anti-human IL-6R monoclonal antibody tocilizumab biosimilar was produced in mammalian cells.
Specificity/Sensitivity	The in vivo grade tocilizumab biosimilar specifically binds to the human interleukin-6 receptor (IL-6R).
Applications	ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by tocilizumab.
Form Of Antibody	0.2 uM filtered solution, pH 6.5, no stabilizers or preservatives.
Endotoxin	<1 EU per 1 mg of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The research grade tocilizumab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note	The research grade tocilizumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Orleave a message with a formal purchase order (PO) Or credit card.

Description

C032P: Tocilizumab Biosimilar, Anti-human IL-6R Monoclonal Antibody

Recombinant Humanized IgG1 Monoclonal Antibody.

Background

What is tocilizumab biosimilar research grade? Tocilizumab biosimilar uses the same protein sequences as the therapeutic antibody tocilizumab. Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. Interleukin 6 (IL-6) is a pro-inflammatory cytokine produced by cells including T-cells, B-cells, lymphocytes, monocytes, fibroblasts. IL-6 rapidly induces C-reactive protein, serum amyloid A, fibrinogen, haptoglobin, and α-1-antichymotrypsin while inhibiting production of fibronectin, albumin, and transferrin. IL-6 also induces antibody production, induces cytotoxic T-cell differentiation, and inhibits regulatory T-cell differentiation. Tocilizumab binds soluble and membrane bound IL-6 receptors, preventing IL-6 mediated inflammation.

Syd Labs also provides the following anti-IL antibody biosimilar proteins:
Pascolizumab Biosimilar, research grade, anti-human IL-4 monoclonal antibody
Sarilumab Biosimilar, research grade, anti-human IL-6/IL-6R monoclonal antibody
Secukinumab Biosimilar, research grade, anti-human IL-17/IL-17a monoclonal antibody
Briakinumab Biosimilar, research grade, anti-human IL-12/IL-23 monoclonal antibody
Ustekinumab Biosimilar, research grade, anti-human IL-12/IL-23 monoclonal antibody

Please remember our product information: Tocilizumab Biosimilar, IL-6R Monoclonal Antibody: C032P Syd Labs

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