Pascolizumab Biosimilar, Anti-human IL-4 Monoclonal Antibody

Catalog No.	C059P
Product Name	Pascolizumab Biosimilar, Anti-human IL-4 Monoclonal Antibody
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Source/Host	The anti-human Interleukin-4 (IL-4) monoclonal antibody pascolizumab biosimilar was produced in mammalian cells.
Specificity/Sensitivity	The in vivo grade pascolizumab biosimilar specifically binds to the human Interleukin-4 (IL-4).
Applications	ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by pascolizumab.
Form Of Antibody	0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin	< 0.1 EU per 1 ug of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The research grade pascolizumab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

C059P: Pascolizumab Biosimilar (Research Grade), Anti-human IL-4 Monoclonal Antibody

Recombinant Humanized IgG1 Monoclonal Antibody.

Background

Pascolizumab Biosimilar uses the same protein sequences as the therapeutic antibody pascolizumab.

Pascolizumab is a humanized monoclonal antibody with therapeutic potential in asthma direct against interleukin-4 (IL-4). In 2002, in vitro studies showed that pascolizumab could effectively neutralize the bioactivity of IL-4, and the binding of pascolizumab to IL-4 had a slow dissociation rate.

Interleukin-4 (IL-4), the target molecular of pascolizumab, is an important cytokine in the early stages of asthma. IL-4 is mainly produced by activated T cells and also comes from a variety of cytokines. IL-4 is a cytokine produced by activated T cells monocytes basophils mast cells and eosinophils. IL-4 binds to IL-4Rα on the surface of effector cells to form dimer between IL-4Rα and γc or IL-13 Rα1, and phosphorylated at the tail of intracellular domain. Then a signal transduction complex is assembled in the intracellular domain of the dimer, and downstream intracellular molecules are activated to promote the transcription of the target gene. The main biological signal transduction pathways involved by IL-4 are JAK-STAT pathway, Ras-ERK pathway and PI3K-PKB pathway. IL-4 has multiple biological functions and therapeutic effects on swelling, hypersensitivity, rheumatoid arthritis, hematopoietic stem cell transplantation, pregnancy, aplastic anemia and ischemic heart disease. In allergic asthma, Th2 cells may resist the immunosuppressive effect of Treg by secreting IL-4, which can interact with IL-4R expressed on the Treg cell, and inhibiting the expression of Foxp3 through STAT6 signaling pathway, affecting the occurrence and development of asthma. Studies have shown that IL-4 mediates important pro-inflammatory effects in asthma, such as induction of IgE-like rearrangement, expression of vascular cell adhesion molecule-1(VCAM-1), promoting eosinophil migration and release of cytokines. Pascolizumab is a monoclonal antibody that neutralizes IL-4, to inhibit asthma-related responses such as activation of T (H)-2 cells and production of immunoglobulin E.

Syd Labs also provides the following anti-IL antibody biosimilar proteins:
Briakinumab Biosimilar, research grade, anti-human IL-12/IL-23 monoclonal antibody
Pascolizumab Biosimilar, research grade, anti-human IL-4 monoclonal antibody
Secukinumab Biosimilar, research grade, anti-human IL-17/IL-17a monoclonal antibody
Tocilizumab Biosimilar, research grade, anti-human IL-6/IL-6R monoclonal antibody
Ustekinumab Biosimilar, research grade, anti-human IL-12/IL-23 monoclonal antibody

Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg. Syd Labs also introduces mutations to the antibody biosimilars including engineering or switching the isotypes or Fc engineering, such as Fc silent.

Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls. Syd Labs provides the following in vivo grade recombinant human IgG1 kappa isotype control antibody proteins and mutants:

In vivo grade recombinant human IgG1 isotype control antibody
In vivo grade recombinant human IgG1 Fc protein
In vivo grade recombinant human IgG1-D265A isotype control antibody
In vivo grade recombinant human IgG1-N297A isotype control antibody
In vivo grade recombinant human IgG1-D265A N297A isotype control antibody
In vivo grade recombinant human IgG1-L234A L235A P329G (LALAPG) isotype control antibody

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Additional information

Size	1 mg, 20 mg, 5 mg

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