Natalizumab Biosimilar, Anti-human Integrin alpha 4 (α4) Monoclonal Antibody | C055P

Catalog No.	C055P
Product Name	Natalizumab Biosimilar, Anti-human Integrin alpha 4 (α4) Monoclonal Antibody | C055P
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	ITGA4, CD49D, IA4, integrin subunit alpha 4
Summary	Recombinant Humanized IgG4 Monoclonal Antibody.
Source/Host	The anti-human Integrin α4 monoclonal antibody natalizumab biosimilar was produced in the natalizumab biosimilar CHO stable cell line.
Specificity/Sensitivity	The in vivo grade natalizumab biosimilar specifically binds to the human Integrin α4.
Applications	ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by natalizumab.
Form Of Antibody	0.2 uM filtered solution, pH 6.0, no stabilizers or preservatives.
Endotoxin	< 1 EU per 1 mg of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The research grade natalizumab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note	The research grade Natalizumab biosimilar protein is for research use only (RUO). Recombinant human IgG4 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Orleave a message with a formal purchase order (PO) Or credit card.

Description

C055P: Natalizumab Biosimilar, Integrin alpha 4 Monoclonal Antibody

Recombinant Humanized IgG4 Monoclonal Antibody.

Background

Natalizumab Biosimilar uses the same protein sequences as the therapeutic antibody natalizumab.

Natalizumab is a monoclonal anti-integrin antibody which binds to the alpha 4 subunit of integrins to prevent migration of immune cells, and is used to treat Crohn’s disease or multiple sclerosis.

Humanized IgG4k monoclonal antibody produced in murine myeloma cells. Natalizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to a4-integrin.

Binds to the α4-subunit of α4b 1 and α4b 7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the α4-mediated adhesion of leukocytes to their counter-receptor(s).

Syd Labs also provides the following anti-integrin alpha 4 antibody biosimilar proteins:
Volociximab Biosimilar, research grade, anti-human integrin α5β1 monoclonal antibody

Please remember our product information: Natalizumab Biosimilar, Integrin alpha 4 Monoclonal Antibody: C055P Syd Labs

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