RPC-1063 (CAS No.: 11306760-87-1), a Potent and Selective S1P1 and S1P5 Receptor Agonist with EC50s of 410 pM and 11 nM in [35S]-GTPγS Binding, Respectively. >98% Purity. Synonyms: Ozanimod, RPC1063, sphingosine-1-phosphate receptor subtypes 1, sphingosine-1-phosphate receptor...
ND-646 (CAS No.: 1434639-57-2), an Orally Bioavailable and Steric Inhibitor of Acetyl-CoA Carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for Recombinant hACC1 and hACC2, Respectively. >99% Purity. Synonyms: Acetyl-CoA Carboxylase, ACC For Research Use Only.
TAK-931 (CAS No.: 1330782-76-7), A Selective and ATP-Competitive Cell Division Cycle 7 (CDC7) Kinase Inhibitor. Synonyms: cell division cycle 7 inhibitor TAK-931, Simurosertib, TAK931, CDC7 kinase inhibitor
Cintirorgon (CAS No.: 2055536-64-4), is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression,...
Darovasertib (CAS No.: 1874276-76-2), is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has...
M-3258 (CAS No.: 2285330-15-4), orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. Synonyms: M3258, M 3258, M-3258,...
AVN944 (CAS No.: 297730-17-7), a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2. Synonyms: AVN-944, VX-944, VX944, Inosine Monophosphate Dehydrogenase (IMPDH), IMPDH1, IMPDH2 For Research Use Only.
Lorlatinib (PF-06463922) (CAS No.: 1454846-35-5) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor. It has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Its purity is...
