Anti-mouse MHC Class II (I-A) Antibody (Clone:Y-3P) | PA007553.m2
$150.00 – $900.00
Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
- Details & Specifications
- References
| Catalog No. | PA007553.m2a |
|---|---|
| Product Name | In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | Aalpha, H 2Aa, H2Aa, H2-Aa, Ia 1, Ia1, IAalpha, MHC Class II |
| Clone | Y-3P. |
| Isotype | Mouse IgG2a kappa. |
| Source/Host | The anti-mouse MHC Class II (I-A) monoclonal antibody (clone: Y-3P) was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade recombinant mouse monoclonal antibody (clone: Y-3P) specifically binds to mouse MHC Class II (I-A) . |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse MHC Class II (I-A) protein. |
| Form Of Antibody | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The in vivo grade recombinant anti-mouse MHC Class II (I-A) monoclonal antibody of clone Y-3P is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
PA007553.m2a: In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa
Recombinant Mouse IgG2a Monoclonal Antibody.
References of Anti-Mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P)
1. Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells.
Younes, S. A., et al.PLoS Biol. 2011 Oct;9(10):e1001171. doi: 10.1371/journal.pbio.1001171. PMID: 22022231; PMCID: PMC3191130
“One approach to evaluating the importance of antigen stimulation in T-cell dynamics is to determine whether proliferation can be blocked by anti-MHC class II antibodies. …To that end, we utilized FcγR-/- mice so that the anti-class II antibody would not block T-cell responses by elimination of antigen-presenting cells. …In such mice, anti-class II antibodies powerfully inhibit antigen-specific in vivo responses. …Neither anti-IL-15 nor anti-IL-7Rα had any inhibitory effect, but Y3P almost completely inhibited proliferation, indicating that the expansion of cells in this lymphopenic setting required recognition of MHC and presumably of peptide/MHC complexes. …Here we have shown that the in situ proliferation of MP cells is not inhibited by anti-MHC class II antibody, using a reagent that strikingly inhibits the proliferation of antigen-specific cells in response to antigen challenge and that blocks the rapid proliferation of MP cells transferred to lymphopenic recipients.”
For more technical references or data sheets regarding the Recombinant Anti-Mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P) formats, please contact our scientific support team at message@sydlabs.com.
In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa from: In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa: PA007553.m2a
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