GSK923295
Synonyms: GSK-923295. GSK 923295 GSK923295 (GSK-923295) is a first-in-class high affinity antimitotic inhibitor of centromere-associated protein E (CENP-E), potently and allosterically inhibiting CENP-E ATPase activity (Ki = 3.2 nM) [1]. GSK923295 displays a broad-spectrum antiproliferative activity...
Lorlatinib (PF-06463922)
Lorlatinib (PF-06463922) (CAS No.: 1454846-35-5) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor. It has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Its purity is...