DOXORUBICIN

Catalog No.	APIM050318
Product Name	DOXORUBICIN

Description

Background Information:

Doxorubicin hyrdrochloride is an anthracycline antibiotic with
antineoplastic activity. Doxorubicin, isolated from the bacterium
Streptomyces peucetius var. caesius, is the hydroxylated congener of
daunorubicin. Doxorubicin intercalates between base pairs in the DNA
helix, thereby preventing DNA replication and ultimately inhibiting
protein synthesis. Additionally, doxorubicin inhibits topoisomerase II
which results in an increased and stabilized cleavable enzyme-DNA linked
complex during DNA replication and subsequently prevents the ligation
of the nucleotide strand after double-strand breakage. Doxorubicin also
forms oxygen free radicals resulting in cytotoxicity secondary to lipid
peroxidation of cell membrane lipids; the formation of oxygen free
radicals also contributes to the toxicity of the anthracycline
antibiotics, namely the cardiac and cutaneous vascular effects.

Reference:

1. Liu YY, Gupta V, Patwardhan GA, Bhinge K, Zhao Y, Bao J, Mehendale
H, Cabot MC, Li YT, Jazwinski SM. Glucosylceramide synthase upregulates
MDR1 expression in the regulation of cancer drug resistance through
cSrc and beta-catenin signaling. Mol Cancer. 2010 Jun 11;9(1):145. [Epub
ahead of print] PubMed PMID: 20540746.
2. Zaremba T, Thomas H, Cole M, Plummer ER, Curtin NJ.
Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1
(PARP-1) activity and expression and its implication for PARP inhibitors
in clinical trials. Cancer Chemother Pharmacol. 2010 May 21. [Epub
ahead of print] PubMed PMID: 20490796.
3. Angelini A, Di Ilio C, Castellani ML, Conti P, Cuccurullo F.
Modulation of multidrug resistance p-glycoprotein activity by flavonoids
and honokiol in human doxorubicin- resistant sarcoma cells
(MES-SA/DX-5): implications for natural sedatives as chemosensitizing
agents in cancer therapy. J Biol Regul Homeost Agents. 2010
Apr-Jun;24(2):197-205. PubMed PMID: 20487633.

APIM050318: DOXORUBICIN

CAS No.: 23214-92-8.
Molecular Formula: C₂₇H₂₉NO₁₁ ? HCl ? 0.5 x H₂O.
Molecular Weight: 589.
Purity: 99% (HPLC).
QC: HPLC, ¹HNMR, Quantitative Elemental Analysis.
Solubility: Soluble in water.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.

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