GSK923295

GSK923295

$120.00$495.00

In stock

$120.00$495.00

Synonyms: GSK-923295. GSK 923295

GSK923295 (GSK-923295) is a first-in-class high affinity antimitotic inhibitor of centromere-associated protein E (CENP-E), potently and allosterically inhibiting CENP-E ATPase activity (Ki = 3.2 nM) [1]. GSK923295 displays a broad-spectrum antiproliferative activity against a range of human tumor xenografts grown in nude mice, including models of colon, breast, ovarian, lung and other tumors. It it currently in clinical evaluations.

Store
SKU: APIM050303 Category:
Clear
View cart
Catalog No. APIM050303
Product NameGSK923295

Description

APIM050303: GSK923295 (GSK-923295)

CAS No.: 1088965-37-0

IUPAC/Chemical Name: 3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

Molecular Formula: C32H38ClN5O4

Molecular Weight: 592.1

Purity: 99.5% chemically pure (achiral HPLC), 100% optically pure (chiral HPLC)

QC: MS, 1HNMR, HPLC, Chiral HPLC, and Quantitative Elemental Analysis

Solubility: soluble in DMSO (59.6 mg/ml, 100mM)

Storage: Store at 0°C (short term), -20°C (long term), desiccated

Background Information:

GSK923295 (GSK923295) is a first-in-class high affinity antimitotic inhibitor of centromere-associated protein E (CENP-E), potently and allosterically inhibiting CENP-E ATPase activity with a Ki value of 3.2nM (Ref. 1). Display a broad-spectrum antiproliferative activity against a range of human tumor xenografts grown in nude mice, including models of colon, breast, ovarian, lung and other tumors. It is currently in clinical evaluations.

 

No more offers for this product!