ABflo® 488 Rabbit anti-Human HER2/ErbB2 mAb (A23182)
$290.00 – $768.00
Abclonal ABflo® 488 Rabbit anti-Human HER2/ErbB2 mAb (Catalog Number: A23182) encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors.
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| Catalog No. | A23182 |
|---|---|
| Product Name | ABflo® 488 Rabbit anti-Human HER2/ErbB2 mAb (A23182) |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Synonyms | NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2) |
| Gene Name | ERBB2 |
| Protein Name | ERBB2 |
| Uniprot/Swissprot ID | P04626 |
| Gene ID | 2064 |
| Clonality | Monoclonal |
| Source/Host | Rabbit |
| Reactivity | Human |
| Conjugate | ABflo® 488. Ex:491nm. Em:516nm. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
A23182: ABflo® 488 Rabbit anti-Human HER2/ErbB2 mAb
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Immunogen Information about ABflo® 488 Rabbit anti-Human HER2/ErbB2 mAb (A23182)
Immunogen：Recombinant fusion protein containing a sequence corresponding to amino acids 23-652 of human HER2/ErbB2(NP_004439.2)
Sequence：TQVCTGTDMK LRLPASPETH LDMLRHLYQG CQVVQGNLEL TYLPTNASLS FLQDIQEVQG YVLIAHNQVR QVPLQRLRIV RGTQLFEDNY ALAVLDNGDP LNNTTPVTGA SPGGLRELQL RSLTEILKGG VLIQRNPQLC YQDTILWKDI FHKNNQLALT LIDTNRSRAC HPCSPMCKGS RCWGESSEDC QSLTRTVCAG GCARCKGPLP TDCCHEQCAA GCTGPKHSDC LACLHFNHSG ICELHCPALV TYNTDTFESM PNPEGRYTFG ASCVTACPYN YLSTDVGSCT LVCPLHNQEV TAEDGTQRCE KCSKPCARVC YGLGMEHLRE VRAVTSANIQ EFAGCKKIFG SLAFLPESFD GDPASNTAPL QPEQLQVFET LEEITGYLYI SAWPDSLPDL SVFQNLQVIR GRILHNGAYS LTLQGLGISW LGLRSLRELG SGLALIHHNT HLCFVHTVPW DQLFRNPHQA LLHTANRPED ECVGEGLACH QLCARGHCWG PGPTQCVNCS QFLRGQECVE ECRVLQGLPR EYVNARHCLP CHPECQPQNG SVTCFGPEAD QCVACAHYKD PPFCVARCPS GVKPDLSYMP IWKFPDEEGA CQPCPINCTH SCVDLDDKGC PAEQRASPLT
Gene ID：2064
Swiss prot：P04626
Synonyms：NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2)
Calculated MW：138kDa
Observed MW：
Images of ABflo® 488 Rabbit anti-Human HER2/ErbB2 mAb (A23182)
Flow cytometry:1X10^6 HL-60 cells (negative control, Left) and SK-BR-3 cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human HER2/ErbB2 mAb(A23182, 5 μl/Test, orange line) or ABflo® 488 Rabbit IgG isotype control (A22069, 5 μl/Test, blue line). Non-fluorescently stained cells were used as blank control (red line).
Flow cytometry:1X10^6 SK-BR-3 cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069, 5 μl/Test, left) or ABflo® 488 Rabbit anti-Human HER2/ErbB2 mAb(A23182, 5 μl/Test, right).
Please remember our product information: ABflo® 488 Rabbit anti-Human HER2/ErbB2 mAb (Catalog Number: A23182) Abclonal
