Cintirorgon (CAS No.: 2055536-64-4), is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression,...
M-3258 (CAS No.: 2285330-15-4), orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. Synonyms: M3258, M 3258, M-3258,...
Synonyms: GSK-923295. GSK 923295 GSK923295 (GSK-923295) is a first-in-class high affinity antimitotic inhibitor of centromere-associated protein E (CENP-E), potently and allosterically inhibiting CENP-E ATPase activity (Ki = 3.2 nM) [1]. GSK923295 displays a broad-spectrum antiproliferative activity...
AVN944 (CAS No.: 297730-17-7), a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2. Synonyms: AVN-944, VX-944, VX944, Inosine Monophosphate Dehydrogenase (IMPDH), IMPDH1, IMPDH2 For Research Use Only.
