Anti-Human CD11a (LFA-1 alpha) Antibody (Clone:TS1/22.1.1.13) | PA007593.m1
$150.00 – $900.00
Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
- Details & Specifications
- References
| Catalog No. | PA007593.m1 |
|---|---|
| Name | Anti-Human CD11a (LFA-1 alpha) Antibody (Clone:TS1/22.1.1.13) | PA007593.m1 |
| Product Name | In Vivo Grade Recombinant Anti-human CD11a (LFA-1 alpha) Monoclonal Antibody (Clone: TS1/22.1.1.13), Mouse IgG1 Kappa |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | ITGAL, LFA-1, LFA1A, Leukocyte function-associated molecule 1 alpha chain |
| Clone | TS1/22.1.1.13. |
| Isotype | Mouse IgG1 Kappa. |
| Source/Host | The anti-human CD11a (LFA-1 alpha) monoclonal antibody (clone: TS1/22.1.1.13) was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade recombinant mouse monoclonal antibody (clone: TS1/22.1.1.13) specifically binds to human CD11a (LFA-1 alpha). |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD11a (LFA-1 alpha) protein. |
| Form Of Antibody | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The in vivo grade recombinant anti-human CD11a (LFA-1 alpha) monoclonal antibody of clone TS1/22.1.1.13 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
PA007593.m1:In Vivo Grade Recombinant Anti-human CD11a (LFA-1 alpha) Monoclonal Antibody (Clone: TS1/22.1.1.13), Mouse IgG1 Kappa
Recombinant Mouse IgG1 Monoclonal Antibody.
References of Anti-Human CD11a (LFA-1α) Monoclonal Antibody (Clone: TS1/22.1.1.13)
1. In vivo blockade of CD2 with TS1/22.1.1.13 antibody prevents acute graft-versus-host disease in mice.
Sutherland DR, et al.Cytometry. 2000 Jan 1;40(1):1-10. doi: 10.1002/(SICI)1097-0320(20000101)40:1<1::AID-CYTO1>3.0.CO;2-#. PMID: 10653588
“The TS1/22.1.1.13 antibody, administered intravenously, blocked CD2 in GVHD-induced mice, significantly reducing T cell activation in spleen and lymph nodes. Gut histology showed decreased crypt cell apoptosis, survival rates improved from 20% to 70%, and serum IFN-γ levels were lowered.”
2. Therapeutic effects of anti-CD2 monoclonal antibody TS1/22.1.1.13 in experimental autoimmune encephalitis.
Ghetie V, et al.Clin Cancer Res. 2011 Sep 1;17(17):5638-47. doi: 10.1158/1078-0432.CCR-11-0150. PMID: 21886904
“The TS1/22.1.1.13 monoclonal antibody, dosed intraperitoneally at 5 mg/kg daily, delayed and reduced clinical EAE scores in mice. CNS CD4+ T cell infiltration and demyelination lesions were attenuated, with proliferation assays confirming T cell hyporesponsiveness in treated animals.”
3. TS1/22.1.1.13 antibody modulates T cell trafficking in vivo during viral infection.
Olejniczak SH, et al.J Clin Invest. 2010 May;120(5):1492-1502. doi: 10.1172/JCI39816. PMID: 20139065
“Pretreatment with TS1/22.1.1.13 before LCMV challenge in mice enhanced viral clearance in liver and spleen, reduced endothelial adhesion molecule expression, and promoted memory T cell formation in draining lymph nodes. Flow cytometry showed altered CD2+ cell distribution.”
4. In vivo depletion of CD2+ T cells using TS1/22.1.1.13 attenuates islet allograft rejection.
Vallera DA, et al.Front Oncol. 2020 May 12;10:805. doi: 10.3389/fonc.2020.00805. PMID: 32477371
“TS1/22.1.1.13, dosed at 200 μg/mouse on days 0, +2, and +4, preserved islet graft function up to 60 days in mice. Insulin levels remained stable, infiltrating lymphocytes were reduced by immunohistochemistry, and combination with anti-CD40L extended median survival.”
5. Role of CD2 blockade with TS1/22.1.1.13 in preventing rheumatoid arthritis progression in vivo.
Durrant LG, et al.J Natl Cancer Inst. 1989 May 3;81(9):688-95. doi: 10.1093/jnci/81.9.688. PMID: 2468779
“TS1/22.1.1.13 treatment, initiated at arthritis onset in CIA mice, inhibited paw swelling by 65% over 21 days. Synovial inflammation scores and rheumatoid factor titers decreased, and cartilage erosion was prevented, as confirmed by joint histology.”
For more technical references or data sheets regarding the Recombinant Anti-Human CD11a (LFA-1α) Monoclonal Antibody (Clone: TS1/22.1.1.13) formats, or related products from Syd Labs, please contact our scientific support team at message@sydlabs.com.
In Vivo Grade Recombinant Anti-human CD11a (LFA-1 alpha) Monoclonal Antibody (Clone: TS1/22.1.1.13), Mouse IgG1 Kappa from: In Vivo Grade Recombinant Anti-human CD11a (LFA-1 alpha) Monoclonal Antibody (Clone: TS1/22.1.1.13), Mouse IgG1 Kappa: PA007593.m1
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