Trastuzumab Biosimilar, Human IgG3

Trastuzumab Biosimilar, Human IgG3

$375.00

In stock

$375.00

Trastuzumab Biosimilar, Human IgG3. The research grade trastuzumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Trastuzumab biosimilar (clone huMAb 4D5-8) is the humanized anti-human HER2 mouse monoclonal antibody (clone muMAb 4D5).

SKU: C009P.h3
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Catalog No. C009P.h3
Product NameTrastuzumab Biosimilar, Human IgG3
Supplier Name Syd Labs, Inc.
Brand Name Syd Labs
Synonyms Anti-ErbB-2 Humanized Monoclonal Antibody, Anti-c-neu Humanized Monoclonal Antibody
Summary Recombinant Humanized IgG1 Monoclonal Antibody.
Source/Host The monoclonal antibody trastuzumab biosimilar was produced in the trastuzumab biosimilar CHO stable cell line, which is available for licensing to manufacture the trastuzumab biosimilar protein.
Specificity/Sensitivity The research grade trastuzumab biosimilar specifically binds to the human HER2 / ErbB-2 / c-neu.
Applications ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by trastuzumab.
Form Of Antibody 0.2 uM filtered solution, pH 6.0, no stabilizers or preservatives.
Endotoxin < 1 EU per 1 mg of the protein by the LAL method.
Purity >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping The Trastuzumab Biosimilar, Human IgG3 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note The research grade trastuzumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Trastuzumab biosimilar (clone huMAb 4D5-8) is the humanized anti-human HER2 mouse monoclonal antibody (clone muMAb 4D5).
Order Offline Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Orleave a message with a formal purchase order (PO) Or credit card.

Description

C009P.h3: Trastuzumab Biosimilar, Human IgG3

Recombinant Humanized IgG1 Monoclonal Antibody.

Background

Trastuzumab, a humanized monoclonal antibody, interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate.

There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1; HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions; when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.

Syd Labs also provides the following anti-ErbB/HER antibody biosimilar proteins:
Panitumumab Biosimilar (HER1, ErbB-1, EGFR)
Cetuximab Biosimilar (HER1, ErbB-1, EGFR)
Pertuzumab Biosimilar (HER2, ErbB-2, c-neu)

Syd Labs also provides the following research grade antibody biosimilar proteins:
Bevacizumab Biosimilar, research grade (VEGF-A)
Ranibizumab Biosimilar, research grade (VEGF-A, Fab produced in E. coli)
Cetuximab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Panitumumab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Trastuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Pertuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Infliximab biosimilar, research grade (TNF alpha)
Adalimumab biosimilar, research grade (TNF alpha)
Rituximab biosimilar, research grade (CD20)
Denosumab biosimilar, research grade (RANKL, RANK ligand, OPGL, TNFSF11, CD254, TRANCE, ODF)
Palivizumab Biosimilar, research grade (RSV)
Omalizumab biosimilar, research grade (IgE)
Eculizumab biosimilar, research grade (C5)

Syd Labs provides the following research grade antibody biosimilars used in ADCs:
Tusamitamab biosimilar, research grade, anti-human CEACAM5 monoclonal antibody
Rovalpituzumab biosimilar, research grade, anti-human DLL3 monoclonal antibody
Trastuzumab biosimilar, research grade, anti-human HER2 monoclonal antibody
Cofetuzumab biosimilar, research grade, anti-human PTK7 monoclonal antibody
Ifinatamab biosimilar, research grade, anti-human B7-H3 (CD276) monoclonal antibody
Sacituzumab biosimilar, research grade, anti-human Trop-2 monoclonal antibody
Gemtuzumab biosimilar, research grade, anti-human CD33 monoclonal antibody
Polatuzumab biosimilar, research grade, anti-human CD79B monoclonal antibody
Cetuximab biosimilar, research grade, anti-human EGFR monoclonal antibody

Please remember our product information: Trastuzumab Biosimilar, Human IgG3: C009P.h3 Syd Labs

Additional information

Ship from Country

USA

Size

0.5 mg

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