PLX4720

Background Information:

A selective inhibitor of B-RAF protein kinase carrying V600E mutation with a Ki at 13 nM.

Reference:

1. J. Tsai, et al., Discovery of a selective inhibitor of oncogenic
B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci USA.
105(8), 3041-6 (2008).

APIM050229: PLX4720

CAS No.: 918505-84-7.
Molecular Formula: C₁₇H₁₄ClF₂N₃O₃S.
Molecular Weight: 413.8.
Purity: >99% (HPLC at 214 and 254 nm).
QC: LC/MS, ¹HNMR.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.