PLX4032

Background Information:

A selective inhibitor of B-RAF protein kinase carrying V600E mutation with an IC₅₀ of 44 nM.

Reference:

1. Bollag, G., et al., Clinical efficacy of a RAF inhibitor needs
broad target blockade in BRAF-mutant melanoma, Nature, 467, 596-9
(2010).

APIM050228: PLX4032

CAS No.: 1029872-54-5.
Molecular Formula: C₂₃H₁₈ClF₂N₃O₃S.
Molecular Weight: 489.9.
Purity: 99.5% (HPLC at 214 and 254 nm).
QC: HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.