MS-275

Background Information:

A synthetic inhibitor of histone deacetylase (HDAC), Preferentially
inhibits HDAC1 (IC50=300nM) over HDAC3 (IC50=8µM). Has no inhibitory
activity towards HDAC8 (IC50>100µM).

Reference:

1. Rosato, R.R., et al.; The histone deacetylase inhibitor MS-275
promotes differentiation or apoptosis in human leukemia cells through a
process regulated by generation of reactive oxygen species and induction
of p21CIP1/WAF1 1: Cancer Res. 63, 3637 (2003).
2. Simonini, M.V., et al., The benzamide MS-275 is a potent,
long-lasting brain region-selective inhibitor of histone deacetylases,
PNAS, 103, 5, 1587-1592, (2006).

APIM050339: MS-275

CAS No.: 209783-80-2.
Molecular Formula: C₂₁H₂₀N₄O₃ ? 0.2H₂O.
Molecular Weight: 380.0.
Purity: >99% (HPLC).
QC: ¹HNMR, HPLC.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.