Mouse EPHA4 Protein (EPH-MM104)
$243.00 – $810.00
KACTUS Biosystems Mouse EPHA4 Protein (EPH-MM104) (catalog No. EPH-MM104) is expressed from HEK293 with His tag at the C-Terminus.It contains Val20-Thr547.
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| Catalog No. | EPH-MM104 |
|---|---|
| Product Name | Mouse EPHA4 Protein (EPH-MM104) |
| Supplier Name | KACTUS Biosystems |
| Brand Name | KACTUS Biosystems |
| Synonyms | Sek; Sek1; EphA4; HEK8; SEK; TYRO1; EK8 |
| Species | Mouse |
| Source | HEK293 |
| Accession | Q03137-1 |
| Product Tag | C-His |
| Biotinylated | no |
| Exact Sequence | Val20-Thr547 |
| Molecular Weight | The protein has a predicted MW of 59.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per μg by the LAL method. |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | '-20 to -80°C for 12 months as supplied from date of receipt.；-20 to -80°C for 3-6 months in unopened state after reconstitution.；2-8°C for 2-7 days after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
EPH-MM104: Mouse EPHA4 Protein (EPH-MM104)
The expression and activation of EphA4 in the various cell types in a knee joint was upregulated upon an intraarticular injury. To determine if EphA4 signaling plays a role in osteoarthritis, we determined whether deficient EphA4 expression (in EphA4 knockout mice) or upregulation of the EphA4 signaling (with the EfnA4-fc treatment) would alter cellular functions of synoviocytes and articular chondrocytes. In synoviocytes, deficient EphA4 expression enhanced, whereas activation of the EphA4 signaling reduced, expression and secretion of key inflammatory cytokines and matrix metalloproteases.
Please remember our product information: Mouse EPHA4 Protein (EPH-MM104) catalog number: EPH-MM104 KACTUS Biosystems