GSK2879552

Catalog No.	APIM050330
Product Name	GSK2879552

Description

Background Information:

GSK2879552 is an orally bioavailable, potent, selective, and
mechanism-based irreversible inhibitor of Lysine specific demethylase 1
(LSD1). LSDI, a histone H3K4me1/2 demethylase found in various
transcriptional co-repressor complexes, including Histone Deacetylases
(HDAC1/2) and Co-Repressor for Element-1-Silencing Transcription factor
(CoREST). Studies have implicated that LSD1 is a key regulator of the
epigenome that modulates gene expression through post-translational
modification of histones and through its presence in transcriptional
complexes, and is overexpressed in certain tumor cells. Inhibition of
LSD1 enhances H3K4 methylation and increases the expression of
tumor-suppressor genes. GSK2879552, as a first-in-class LSD1 inhibitor
with excellent potency and pharmacological properties, is currently
under clinical evaluation for cancer treatment.

APIM050330: GSK2879552

CAS No.: 1401966-69-5, 1401966-63-9.
Molecular Formula: C₂₃H₂₈N₂O₂ ? 2HCl.
Molecular Weight: 437.4 (or refer to COA, batch-specific).
Purity: 99.9% chemical purity, 100% optical purity, Lot 02.
QC: HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO, in Water.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.

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