AZD-0156 (AZD0156)
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| Catalog No. | APIM050088 |
|---|---|
| Product Name | AZD-0156 (AZD0156) |
Description
Background Information:
ATMK (Ataxia Telangiectasia Mutated Kinase), a serine/threonine protein kinase, is upregulated in a variety of cancer cell types, and activated in response to DNA damage and plays a key role in DNA-strand repair. AZD-0156 (AZD0156) is an orally bioavailable small molecule inhibiting the kinase activity of ATM and ATM-mediated signaling, preventing DNA damage checkpoint activation, disrupting DNA damage repair, inducing tumor cell apoptosis, and leading to cell death in ATM-overexpressing tumor cells. In addition, AZD0156 also sensitizes tumor cells to chemo- and radiotherapy.
APIM050088: AZD-0156 (AZD0156)
CAS No.: 1821428-35-6.
Molecular Formula: C26H31N5O3.
Molecular Weight: 461.6.
Purity: 99.9% (HPLC at 214 and 254 nm).
QC: HPLC, 1H-NMR, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
