Anti-mouse PD-1 / CTLA-4 Bispecific Antibody (Clone: RMP1-14.1 / 9D9) | PA008030.m2cLA
$595.00 – $1,750.00
Recombinant anti-mouse PD-1 / CTLA-4 bispecific antibodies share the variable region sequences with the rat anti-mouse PD-1 antibody (clone number: RMP1-14) and the mouse anti-mouse CTLA-4 antibody (clone number: 9D9). The recombinant mouse IgG2c LALAPG bispecific isotype control antibody available.
- Details & Specifications
- References
| Catalog No. | PA008030.m2cLA |
|---|---|
| Product Name | Anti-mouse PD-1 / CTLA-4 Bispecific Antibody (Clone: RMP1-14.1 / 9D9) | PA008030.m2cLA |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | PD-1 / CTLA4 Bispecific, PD1 / CTLA-4 Bispecific, CTLA4 / PD-1 Bispecific, CTLA-4 / PD-1 Bispecific |
| Clone | RMP1-14.1, the same variable region sequences as the rat anti-mouse PD-1 monoclonal antibody (clone number: RMP1-14). 9D9, the same variable region sequences as the mouse anti-mouse CTLA-4 monoclonal antibody (clone number: 9D9). |
| Isotype | mouse IgG2c, kappa. |
| Applications | immunohistochemistry (IHC), Flow Cytometry (FC), and various in vitro and in vivo functional assays. |
| Form Of Antibody | 0.2 μM filtered solution of 1x PBS. |
| Endotoxin | Less than 1 EU/mg of protein as determined by LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions. |
| Shipping | The in vivo grade recombinant rat anti-mouse PD-1 / CTLA-4 bispecific antibodies are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 3 month from date of receipt, 2 to 8°C as supplied. 12 months from date of receipt, -20°C to -70°C as supplied. |
| Note | Recombinant anti-mouse PD-1 / CTLA-4 bispecific antibodies share the variable region sequences with the rat anti-mouse PD-1 antibody (clone number: RMP1-14) and the mouse anti-mouse CTLA-4 antibody (clone number: 9D9). The recombinant mouse IgG2c LALAPG bispecific isotype control antibody available. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
PA008030.m2cLA: In Vivo Grade Recombinant Anti-mouse PD-1 / CTLA-4 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / 9D9)
The in vivo grade recombinant anti-mouse PD-1 / CTLA-4 bispecific antibody (mouse IgG2c LALAPG kappa) was produced in mammalian cells.
Background
The rat anti-mouse PD-1 monoclonal antibody (clone No. RMP1-14, rat IgG2a kappa) reacts with the mouse PD-1 protein (CD279 or programmed death-1) encoded by the mouse pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD 1 antibody and the anti-mouse PD L1 antibody which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The RMP1-14 antibody blocks the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein.
The 9D9 antibody blocks the mouse cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an inhibitory molecule that competes with the stimulatory CD28 for binding to B7 on antigen presenting cells. CTLA-4 and CD28 are both presented on the surface of T-cells.
It is under investigation how the recombinant anti-mouse PD-1 / CTLA-4 bispecific antibodies (RMP1-14.1 / 9D9) behave different from the individual monoclonal antibodies and their combination.
Our recombinant anti-mouse PD-1 / CTLA-4 bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody (hybridoma clone name or number: RMP1-14) and the mouse anti-mouse CTLA-4 antibody (hybridoma clone name or number: 9D9).
Recombinant anti-HEL / HEL Bispecific Isotype Control Antibodies:
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG1 Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2a Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2c Kappa Bispecific Isotype Control Antibody
Syd Labs provides the following anti-mouse PD-1 / CTLA-4 bispecific antibodies:
In vivo grade recombinant anti-mouse PD-1 / CTLA-4 bispecific antibodies (Clone RMP1-14.1 / 9D9)
In vivo grade recombinant anti-mouse PD-1 / CTLA4 bispecific antibodies (Clone 29F.1A12.1 / 9D9)
Syd Labs provides the following anti-mouse PD1 (PD-L1) and CTLA-4 monoclonal antibodies:
In vivo grade recombinant anti-mouse PD-1 monoclonal antibodies (Clone RMP1-14.1)
In vivo grade recombinant anti-mouse PD 1 monoclonal antibodies (Clone 29F.1A12.1)
In vivo grade recombinant anti-mouse PD-L1 monoclonal antibodies (Clone 10F.9G2.1)
In vivo grade recombinant anti-mouse CTLA-4 monoclonal antibodies (Clone 9D9)
Syd Labs provides the following anti-mouse PD-1 / VEGFA bispecific antibodies:
In vivo grade recombinant anti-mouse PD-1 /VEGF-A bispecific antibodies (Clone RMP1-14.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD1 / VEGFA bispecific antibodies (Clone 29F.1A12.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD-1 / VEGF bispecific antibodies (Clone RMP1-14.1 / G6-23)
In vivo grade recombinant anti-mouse PD1 / VEGF bispecific antibodies (Clone 29F.1A12.1 / G6-23)
In vivo grade recombinant anti-mouse PD 1 / VEGF bispecific antibodies (Clone RMP1-14.1 / G6-31)
In vivo grade recombinant anti-mouse PD-1 / VEGF A bispecific antibodies (Clone 29F.1A12.1 / G6-31)
Syd Labs provides the following anti-mouse PD-L1 / VEGFA bispecific antibodies:
In vivo grade recombinant anti-mouse PD-L1 / VEGF A bispecific antibodies (Clone 10F.9G2.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD-L1 / VEGF bispecific antibodies (Clone 10F.9G2.1 / G6-23)
In vivo grade recombinant anti-mouse PDL1 / VEGF bispecific antibodies (Clone 10F.9G2.1 / G6-31)
Syd Labs provides the following anti-mouse PD-1 / TIGIT bispecific antibodies:
In vivo grade recombinant anti-mouse PD-1 / TIGIT bispecific antibodies (Clone 29F.1A12.1 / 1F4)
In vivo grade recombinant anti-mouse TIGIT / PD-1 bispecific antibodies (Clone 1F4 / 29F.1A12.1)
In Vivo Grade Recombinant Anti-mouse PD-1 / CTLA-4 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / 9D9) from: In Vivo Grade Recombinant Anti-mouse PD-1 / CTLA-4 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / 9D9): PA008030.m2cLA Syd Labs
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