Description

PA007625.r2b: In Vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody (Clone: YTS191), Rat IgG2b Kappa

Recombinant rat IgG2b Monoclonal Antibody.

References of Anti-Mouse CD4 Monoclonal Antibody (Clone: YTS191)

1. Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells.
Burrack, K. S., et al.PLoS Pathog. 2015 Oct 5;11(10):e1005191. doi: 10.1371/journal.ppat.1005191. PMID: 26436766
“Arg1 activity has also been associated with higher viral loads and lower CD4+ T cell counts from HIV-seropositive patients [33,42] and with inhibition of CD8+ T cell responses in hepatitis B virus (HBV) and hepatitis C virus (HCV)-infected patients. …To investigate this hypothesis, WT and LysMcre;Arg1F/F mice were treated with anti-CD4 and anti-CD8 antibodies, or an isotype control antibody, on days 7 and 12 pi to deplete CD4+ and CD8+ T cells. …After gating on lymphocytes, CD8+ T cells were identified by staining positive for CD3 and CD8; CD4+ T cells were identified by gating on CD3+CD8- cells followed by gating on CD3+CD4+ cells. …The three activation markers that we evaluated are known to be upregulated on antigen-experienced T cells: CD44, CD11a, and CD69. …Both CD4+ and CD8+ T cell subsets isolated from LysMcre;Arg1F/F mice expressed increased levels of IFN-γ compared to T cells sorted from WT mice.”

2. Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells.
Fahey, L. M., et al.J Exp Med. 2011 May 9;208(5):987-99. doi: 10.1084/jem.20101773. PMID: 21536743
“We now demonstrate that CD4 T cell function is not extinguished as a result of viral persistence. …Depending on the level of TCR stimulation and the composition of co-stimulatory and inflammatory signals, CD4 T cells differentiate into a variety of helper subsets that in turn orchestrate diverse immune responses. …CD4 T cells continue to help CD8 T cells during persistent viral infection, allowing continued control over virus replication. …Given that ongoing antiviral immune responses continually exert control over virus replication throughout persistent infection and that CD4 T cells play an integral role in this process, we sought to define how viral persistence impacts CD4 T cell differentiation such that it is capable of maintaining antiviral immunity in the face of prolonged periods of viral replication. …Thus, we demonstrate that CD4 T cells are not without function during viral persistence, but instead that their developmental program is redirected from promoting memory T and B cell differentiation after acute viral infection and toward a T helper subset that sustains multiple immune parameters to fight persistent viral infection.”

For more technical references or data sheets regarding the Recombinant Anti-Mouse CD4 Monoclonal Antibody (Clone: YTS191) formats, please contact our scientific support team at message@sydlabs.com.

In Vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody (Clone: YTS191), Rat IgG2b Kappa from: In Vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody (Clone: YTS191), Rat IgG2b Kappa: PA007625.r2b