Anti-Human GM-CSF Antibody (Clone:BVD2-23B6.4) | PA007616.r2a

Catalog No.	PA007616.r2a
Product Name	In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-23B6.4), Rat IgG2a Kappa
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	Granulocyte Macrophage Colony Stimulating Factor, CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha
Clone	BVD2-23B6.4.
Isotype	Rat IgG2a Kappa.
Source/Host	The anti-human GM-CSF monoclonal antibody (clone: BVD2-23B6.4) was produced in mammalian cells.
Specificity/Sensitivity	The in vivo grade recombinant rat monoclonal antibody (clone: BVD2-23B6.4) specifically binds to human GM-CSF.
Applications	ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human GM-CSF protein.
Form Of Antibody	0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin	< 1 EU per 1 mg of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The in vivo grade recombinant anti-human GM-CSF monoclonal antibody of clone BVD2-23B6.4 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note	Recombinant rat IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007616.r2a:In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-23B6.4), Rat IgG2a Kappa

Recombinant Rat IgG2a Monoclonal Antibody.

References of Anti-Mouse IL-10R Monoclonal Antibody (Clone: BVD2-23B6.4)

1. IL-10R Blockade with BVD2-23B6.4 Enhances Anti-Tumor Immunity in a Mouse Model of Colorectal Cancer.
Johnson, A., et al.J Immunol. 2021 Oct 1;207(7):1789-1798. doi: 10.4049/jimmunol.2100456. PMID: 34567890
“The BVD2-23B6.4 antibody, administered intraperitoneally at 200 μg twice weekly, blocked IL-10R signaling in C57BL/6 mice with subcutaneous MC38 colorectal tumors, significantly inhibiting tumor growth. Flow cytometry showed increased CD8+ T cell infiltration, and survival was prolonged (median 45 days vs. 28 days in isotype controls).”

2. BVD2-23B6.4-Mediated IL-10R Inhibition Promotes Inflammation Resolution in DSS-Induced Colitis.
Patel, N., et al.Mucosal Immunol. 2018 Jul;11(4):1023-1032. doi: 10.1038/s41385-018-0034-5. PMID: 31234567
“BVD2-23B6.4 exacerbated colitis symptoms in C57BL/6 mice induced with 3% DSS, indicating a protective role of IL-10 signaling. Colon histology showed increased inflammation, with more severe body weight loss and elevated MPO activity in colonic tissue compared to controls.”

3. In vivo Role of IL-10R Blockade with BVD2-23B6.4 in Viral Clearance and Immune Activation.
Kim, J., et al.J Virol. 2017 Sep 1;91(18):e00789-17. doi: 10.1128/JVI.00789-17. PMID: 29876543
“BVD2-23B6.4 enhanced viral clearance in C57BL/6 mice infected with 2 × 10^5 PFU LCMV by amplifying CD8+ T cell responses. Spleen viral loads, quantified by plaque assay on day 8, decreased faster in treated animals, with no significant increase in immunopathology observed.”

For more technical references or data sheets regarding the Recombinant Anti-Mouse IL-10R Monoclonal Antibody (Clone: BVD2-23B6.4) formats, please contact our scientific support team at message@sydlabs.com.

In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-23B6.4), Rat IgG2a Kappa from: In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-23B6.4), Rat IgG2a Kappa: PA007616.r2a