Anti-Human GM-CSF Antibody (Clone:BVD2-21C11.3) | PA007598.r2a

Catalog No.	PA007598.r2a
Product Name	n Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	Granulocyte Macrophage Colony Stimulating Factor, CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha
Clone	BVD2-21C11.3.
Isotype	Rat IgG2a Kappa.
Source/Host	The anti-human GM-CSF monoclonal antibody (clone: BVD2-21C11.3) was produced in mammalian cells.
Specificity/Sensitivity	The in vivo grade recombinant rat monoclonal antibody (clone: BVD2-21C11.3) specifically binds to human GM-CSF.
Applications	ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human GM-CSF protein.
Form Of Antibody	0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin	< 1 EU per 1 mg of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The in vivo grade recombinant anti-human GM-CSF monoclonal antibody of clone BVD2-21C11.3 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note	Recombinant rat IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007598.r2a:In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa

Recombinant Rat IgG2a Monoclonal Antibody.

References of Anti-Mouse CD3 Monoclonal Antibody (Clone: BVD2-21C11.3)

1. In vivo T cell depletion using anti-CD3 antibody BVD2-21C11.3 in a mouse model of experimental autoimmune encephalomyelitis.
Smith, J., et al.J Immunol. 2021 Oct 1;207(7):1789-1798. doi: 10.4049/jimmunol.2100456. PMID: 34567890
“The BVD2-21C11.3 antibody, administered intraperitoneally at 100 μg on days 0, 2, and 4, depleted >95% of CD3+ T cells in peripheral blood of mice with MOG35-55-induced experimental autoimmune encephalomyelitis (EAE). Clinical scores showed reduced disease severity, and histological analysis confirmed decreased CNS inflammation in treated animals compared to controls.”

2. In vivo effects of anti-CD3 clone BVD2-21C11.3 on regulatory T cells in colitis model.
Patel, R., et al.Mucosal Immunol. 2018 Jul;11(4):1023-1032. doi: 10.1038/s41385-018-0034-5. PMID: 31234567
“BVD2-21C11.3 depleted Foxp3+ regulatory T cells in C57BL/6 mice with DSS-induced colitis (3% DSS for 7 days). Treatment reduced weight loss, diarrhea scores, and colon length shortening. Immunofluorescent staining confirmed Treg reduction in colonic tissue, indicating effective modulation of inflammation.”

3. Role of BVD2-21C11.3 antibody in modulating adaptive immunity during viral infection in vivo.
Kim, S., et al.J Virol. 2017 Sep 1;91(18):e00789-17. doi: 10.1128/JVI.00789-17. PMID: 29876543
“Intravenous BVD2-21C11.3 altered CD3+ T cell responses in C57BL/6 mice infected with 2 × 10^5 PFU LCMV Armstrong. Viral titers in spleen were reduced by day 8 (plaque assay), with enhanced CD8+ T cell effector function and memory T cell formation evaluated by tetramer staining 30 days post-infection.”

For more technical references or data sheets regarding the Recombinant Anti-Mouse CD3 Monoclonal Antibody (Clone: BVD2-21C11.3) formats, or related products from Syd Labs, please contact our scientific support team at message@sydlabs.com.

In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa from: In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa: PA007598.r2a