Recombinant Anti-human CA19-9 Monoclonal Antibody (1116-NS-19-9), In Vivo PA007617.m1 Syd Labs
In Vivo Grade Recombinant Anti-human CA19-9 Monoclonal Antibody (Clone 1116-NS-19-9), Mouse IgG1 Kappa

Anti-Human CA19-9 Antibody (Clone:1116-NS-19-9) | PA007617.m1

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Recombinant Anti-human CA19-9 Monoclonal Antibody (1116-NS-19-9), In Vivo PA007617.m1 Syd Labs

Anti-Human CA19-9 Antibody (Clone:1116-NS-19-9) | PA007617.m1

$150.00 – $900.00

In stock

$150.00 – $900.00

Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.

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Order Offline:
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Catalog No. PA007617.m1
Product Name In Vivo Grade Recombinant Anti-human CA19-9 Monoclonal Antibody (Clone: 1116-NS-19-9), Mouse IgG1 Kappa
Supplier Name Syd Labs, Inc.
Brand Name Syd Labs
Synonyms CA19.9, Ovarian tumor antigen, Pancreatic tumor antigen, Sialyl Lewis a
Clone 1116-NS-19-9.
Isotype Mouse IgG1 Kappa.
Source/Host The anti-human CA19-9 monoclonal antibody (clone: 1116-NS-19-9) was produced in mammalian cells.
Specificity/Sensitivity The in vivo grade recombinant mouse monoclonal antibody (clone: 1116-NS-19-9) specifically binds to human CA19-9.
Applications ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CA19-9 protein.
Form Of Antibody 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin < 1 EU per 1 mg of the protein by the LAL method.
Purity >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping The in vivo grade recombinant anti-human CA19-9 monoclonal antibody of clone 1116-NS-19-9 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007617.m1:In Vivo Grade Recombinant Anti-human CA19-9 Monoclonal Antibody (Clone: 1116-NS-19-9), Mouse IgG1 Kappa

Recombinant Mouse IgG1 Monoclonal Antibody.

References of Anti-Human CA19-9 Monoclonal Antibody (Clone: 1116-NS-19-9)

1. Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma.
Kozak, R. P., et al.Sci Rep. 2024 Feb 3;14(1):2698. doi: 10.1038/s41598-024-52698-8. PMID: 38307988
“The 1116-NS-19-9 antibody detected CA19-9 in pancreatic ductal adenocarcinoma (PDAC) samples via semi-quantitative IHC, showing heterogeneous expression with variable intensity in ductal structures. CD175, consistently positive in tumor cells, was identified as a potential complementary biomarker to CA19-9, which was co-detected with HECA-452 for CD15s.”

2. Tumor‐Associated Carbohydrate Antigen 19–9 (CA 19–9), a Promising Target for Antibody‐Based Detection, Diagnosis, and Immunotherapy of Cancer.
Nakisa, M., et al.ChemMedChem. 2024 Nov 7;e202400491. doi: 10.1002/cmdc.202400491. PMID: 39482752
“The 1116-NS-19-9 monoclonal antibody identified CA19-9 in 1979, with a constructed scFv (RA9-23) showing stronger binding to WiDr and Capan-2 cell lines than the native antibody. Increased CA19-9 expression promoted tumor metastasis via E-selectin binding, and in mice, it caused severe pancreatitis through EGFR signaling hyperactivation.”

3. Carbohydrate antigen 19-9 — tumor marker: Past, present, and future.
Duffy, M. J., et al.World J Gastrointest Surg. 2020 Dec 27;12(12):468-481. doi: 10.4240/wjgs.v12.i12.468. PMID: 33352866
“CA19-9, first identified in 1979 by the 1116-NS-19-9 antibody in the SW1116 colorectal carcinoma cell line, is a sialylated Lewis^a^ antigen associated with pancreatic ductal adenocarcinoma (PDAC). Its utility spans serum, saliva, pancreatic cysts, and immunohistochemical applications, reflecting its role as a key tumor marker in PDAC.”

4. CA 19-9 and Pancreatic Cancer.
Ballehaninna, U. K., et al.Gastroenterol Res Pract. 2013;2013:710836. doi: 10.1155/2013/710836. PMID: 23592950
“CA19-9, a sialylated Lewis^a^ antigen identified by the 1116-NS-19-9 antibody in the SW1116 colorectal carcinoma cell line in 1979, is a component of glycoproteins and mucins. Its concentration, measured by ELISA, aids in detecting pancreatic cancer early, potentially improving prognosis through curative resection.”

For more technical references or data sheets regarding the Recombinant Anti-Human CA19-9 Monoclonal Antibody (Clone: 1116-NS-19-9) formats, please contact our scientific support team at message@sydlabs.com.

In Vivo Grade Recombinant Anti-human CA19-9 Monoclonal Antibody (Clone: 1116-NS-19-9), Mouse IgG1 Kappa from: In Vivo Grade Recombinant Anti-human CA19-9 Monoclonal Antibody (Clone: 1116-NS-19-9), Mouse IgG1 Kappa: PA007617.m1

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