VORINOSTAT

Background Information:

Vorinostat (SAHA) is a small molecule inhibitor of histone deacetylase (HDAC), inhibiting class I and II HDAC with Ki at low nM.

Reference:

1. Kirschbaum M, Frankel P, et al., Phase II Study of Vorinostat for
Treatment of Relapsed or Refractory Indolent Non-Hodgkin’s Lymphoma and
Mantle Cell Lymphoma, J Clin Oncol. 2011 Feb 7. [Epub ahead of print].
2. Stathis A, Hotte S, Chen EX, et al., Phase I study of decitabine in
combination with vorinostat in patients with advanced solid tumors and
non-Hodgkin’s lymphomas, Clin Cancer Res. 2011 Jan 28. [Epub ahead of
print].

APIM050345: VORINOSTAT

CAS No.: 149647-78-9.
Molecular Formula: C₁₄H₂₀N₂O_3.
Molecular Weight: 264.3.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.