VATALANIB

Background Information:

An inhibitor of all known vascular endothelial growth factor receptor
(VEGFR) kinases, and at high concentration, it also inhibits other
tyrosine kinases such as PDGFR, c-Kit and c-FMS.

Reference:

1. K?osowska-Ward?ga A, Hasumi Y, et al., Combination therapy using
imatinib and vatalanib improves the therapeutic efficiency of paclitaxel
towards a mouse melanoma tumor. Melanoma Res. 2010 Oct 21. [Epub ahead
of print].

APIM050253: VATALANIB

CAS No.: 212141-54-3.
Molecular Formula: C₂₀H₁₅ClN₄ ? 2HCl.
Molecular Weight: 419.7.
Purity: >99% (HPLC).
QC: ¹HNMR, HPLC.
Solubility: Soluble in water.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.