TAK-931 (SIMUROSERTIB)
TAK-931 (CAS No.: 1330782-76-7), A Selective and ATP-Competitive Cell Division Cycle 7 (CDC7) Kinase Inhibitor. Synonyms: cell division cycle 7 inhibitor TAK-931, Simurosertib, TAK931, CDC7 kinase inhibitor
ALTIRATINIB (DCC-2701)
Background Information: Abstract (Ref 1): Altiratinib (DCC-2701) was designed based on the rationale of engineering a single therapeutic agent able to address multiple hallmarks of cancer. Specifically, Altiratinib inhibits not only mechanisms of tumor initiation and...
LYC-55716 (CINTIRORGON)
Cintirorgon (CAS No.: 2055536-64-4), is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression,...
M-3258 (M3258, M 3258)
M-3258 (CAS No.: 2285330-15-4), orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. Synonyms: M3258, M 3258, M-3258,...
GSK923295
Synonyms: GSK-923295. GSK 923295 GSK923295 (GSK-923295) is a first-in-class high affinity antimitotic inhibitor of centromere-associated protein E (CENP-E), potently and allosterically inhibiting CENP-E ATPase activity (Ki = 3.2 nM) [1]. GSK923295 displays a broad-spectrum antiproliferative activity...