PF-03758309

Background Information:

PF-03758309 is a potent, orally bioavailable and ATP-competitive
inhibitor of p21-activated kinase (PAK), a downstream effector of the
Rho family functioning as a signaling node for various oncogenic
pathways.

Reference:

1. B. W. Murray, et al., Small-molecule p21-activated kinase
inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and
tumor growth, PNAS U S A, 2010 May 18;107(20):9446-51.
2. Confirmed by a high-precision quantitative elemental analysis.

APIM050223: PF-03758309

CAS No.: 898044-15-0 (free base), 1279034-84-2 (HCl).
Molecular Formula: C₂₅H₃₀N₈OS ? 2HCl.
Molecular Weight: 563.5 (or refer to certificate of analysis, batch-specific).
Purity: >99.5% chem purity (HPLC), 100% optical purity (Chiral HPLC).
QC: HPLC-MS, ¹HNMR, Chiral HPLC and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO, Water.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.