PF-02341066

Background Information:

PF-02341066 (R-Crizotinib) is a cell-permeable, specific
ATP-competitive small-molecule inhibitor of c-Met (Ki =4 nM) and
anaplastic lymphoma kinase (ALK) (IC50 = 28 nM).

Reference:

1. Zou, H.Y., et al, An orally available small-molecule inhibitor of
c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through
antiproliferative and antiangiogenic mechanisms, Cancer Res. 67:
4408-4417 (2007).
2. Bang, Y., et al, Clinical activity of the oral ALK inhibitor
PF-02341066 in ALK-positive patients with non-small cell lung cancer
(NSCLC), J. Clin. Oncol. 28: 3 (2010).

APIM050222: PF-02341066

CAS No.: 877399-52-5.
Molecular Formula: C₂₁H₂₂Cl₂FN₅O ?0.5H₂O.
Molecular Weight: 459.3.
Purity: 100% optical purity (Chiral HPLC), >99% purity (HPLC at 214 and 254 nm).
QC: HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO and water with 2 eq. of acid.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.