OLMUTINIB (BI 1482694, HM71224)

Background Information:

Olmutinib (BI 1482694, HM61713) is a third-generation, orally
bioavailable and irreversible Tyrosine Kinase Inhibitor, potently and
selectively targeting EGFR mutants with Ki values of ~10 nM (in vitro
cell assays, against sensitizing (Del19, L858R) and resistance (T790M)
EGFR mutations), highly selective over Wt EGFR (Ki = >2000nM,
>200-fold selectivity). It is an FDA -designated Breakthrough Therapy
for lung cancer.

APIM050212: OLMUTINIB (BI 1482694, HM71224)

CAS No.: 1353550-13-6.
Molecular Formula: C26H26N6O2S.
Molecular Weight: 486.6.
Purity: >99.5% by HPLC.
QC: HPLC-MS, 1H-NMR, and quantitative elemental analysis report.
Solubility: Refer to Certificate.
Storage: Refer to Certificate.