NVP-TAE684

Background Information:

A potent, selective and efficacious inhibitor of NPM-ALK.

Reference:

1. Galkin, A. V., et al., Identification of NVP-TAE684, a potent,
selective, and efficacious inhibitor of NPM-ALK., Proc Natl Acad Sci
USA, 2007, 104 (1), 270-275.
2. McDermott, U., et al., Genomic Alterations of Anaplastic Lymphoma
Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors,
Cancer Res, 2008, 68(9), 3389-3395.

APIM050211: NVP-TAE684

CAS No.: 761439-42-3.
Molecular Formula: C₃₀H₄₀ClN₇O₃S.
Molecular Weight: 614.22.
Purity: >99% (HPLC at 214 and 254 nm).
QC: MS, HPLC and ¹HNMR.
Solubility:Soluble in DMSO and water with 2 eq. of acid.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.