ODANACATIB

Background Information:

A potent and selective inhibitor of cysteine protease cathepsin K
(IC50 0.2 nM), discriminating against cathepsin B (1034 nM), L (2995
nM), and S (60 nM). The product Odanacatib has been in clinical
evaluation as the first-in-class drug treating postmenopausal women with
osteoporosis.

Reference:

1. J. Y. Gauthier, et al, Bioorganic & Medicinal Chemistry
Letters (2008), 18 (3), 923 – 928.* Perfect HPLC, Chiral HPLC, NMR +
Quantitative Elemental Analysis + appearance (snow-white powder) , no
impurities (not a bit) visible by any analytical methods – a true
testament to the superior quality.

APIM050362: ODANACATIB

CAS No.: 603139-19-1.
Molecular Formula: C₂₅H₂₇F₄N₃O₃S ? 0.1H₂O.
Molecular Weight: 527.4.
Purity: >99.8% chem and optical purity (HPLC and chiral HPLC at 214 and 254 nm).
QC: HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO, Alcohols, Common Organic Solvents.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.