VARESPLADIB (LY315920)

Background Information:

Varespladib (LY315920) is an inhibitor of human and mouse sPLA2 group
IIA, V, and X enzymes with IC50 values in the low nM range.

Reference:

1. DW Snyder, et al., Pharmacology of LY315920/S-5920,
[[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy]
acetate, a potent and selective secretory phospholipase A2 inhibitor: A
new class of anti-inflammatory drugs, SPI., J Pharmacol Exp Ther. 1999
Mar;288(3):1117-24.
2. H. Fraser, et al., Varespladib (A-002), a secretory phospholipase A2
inhibitor, reduces atherosclerosis and aneurysm formation in ApoE-/-
mice, J Cardiovasc Pharmacol. 2009 Jan;53(1):60-5.

APIM050363: VARESPLADIB (LY315920)

CAS No.: 172732-68-2.
Molecular Formula: C₂₁H₂₀N₂O_5.
Molecular Weight: 380.4 (or refer to certificate of analysis, batch-specific).
Purity: 99.9% (by HPLC at 214 and 254 nm).
QC: HPLC-MS, ¹HNMR and Quantitative Elemental Analysis.
Solubility: Refer to Certificate of Analysis.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.